{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:56:21Z","timestamp":1790708181776,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kawasaki disease (KD) is an acute childhood vasculitis in which coronary artery lesions (CALs) determine long\u2010term cardiovascular risk. We evaluated a focused pre\u2010IVIG biomarker profile in relation to baseline Z\u2010score\u2010defined coronary involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether interleukin\u201017A (IL\u201017A), interleukin\u20108 (IL\u20108), and platelet count (PLT) were associated with baseline CAL and to assess the robustness and internal discrimination of this exploratory profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center retrospective exploratory cohort study screened 242 children with suspected KD treated in 2023. After 43 exclusions, 199 children were analyzed (non\u2010CAL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009166; CAL,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933). CAL was defined using pretreatment segment\u2010level coronary Z\u2010scores recorded in the institutional echocardiographic database. To limit model complexity, the primary Firth\u2010penalized logistic model was restricted to three predictors (PLT, IL\u20108, and IL\u201017A; 11 events per predictor). A nine\u2010covariate clinically informed model and illness\u2010timing\/incomplete\u2010KD models were treated as sensitivity analyses. Internal validation used 1000\u2010resample bootstrap optimism correction and 100 repeated stratified fivefold cross\u2010validation with complete refitting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the non\u2010CAL group, children with CAL had higher PLT, IL\u20106, IL\u20108, and IL\u201017A and lower hematocrit (HCT), among other group\u2010level differences. In the primary Firth model, PLT (OR, 3.081 per 100\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L; 95% CI, 1.582\u20136.002), IL\u20108 (OR, 1.167 per 10\u2009pg\/mL; 95% CI, 1.076\u20131.266), and IL\u201017A (OR, 6.555 per 10\u2009pg\/mL; 95% CI, 3.054\u201314.071) were associated with baseline CAL. The apparent AUC was 0.975, the optimism\u2010corrected AUC was 0.972, and the repeated\u2010cross\u2010validation mean AUC was 0.966 (SD, 0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher pre\u2010IVIG IL\u201017A, IL\u20108, and PLT were associated with baseline Z\u2010score\u2010defined CAL. These internally validated but single\u2010center observational findings neither establish mechanism nor justify biomarker\u2010guided imaging or treatment. Prospective multicenter external validation is required before clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70514","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:55:00Z","timestamp":1790240100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u201017A, Interleukin\u20108, and Platelet Count Are Associated With Baseline Coronary Artery Lesions in Children With Kawasaki Disease: A Retrospective Exploratory Cohort Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Cuijie","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine V (International Department) Hebei Children's Hospital, Hebei Clinical Research Center for Children's Health and Diseases Shijiazhuang 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