{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:58:18Z","timestamp":1790708298019,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriatic arthritis (PsA) is a chronic inflammatory disease with complex pathophysiology. Despite advancements in biologic and targeted synthetic disease\u2010modifying antirheumatic drugs (b\/tsDMARDs), treatment responses remain suboptimal for many patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We present a case of a 35\u2010year\u2010old male with refractory PsA who achieved significant clinical improvement through combination therapy with ixekizumab (an IL\u201017 inhibitor) and upadacitinib (a JAK inhibitor), following inadequate responses to multiple monotherapies. A scoping review of the literature was conducted, analyzing studies on dual b\/tsDMARD therapy in PsA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient achieved rapid clinical improvement with complete resolution of articular symptoms, normalization of inflammatory markers, and significant metabolic improvements. The scoping review identified 16 studies, highlighting the potential of multi\u2010target strategies while emphasizing safety concerns such as increased infection risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case and review underscore the promise of combination therapy in PsA while emphasizing the need for further research to optimize its use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70515","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:29:40Z","timestamp":1789133380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combination Treatment of IL\u201017 Inhibitor and JAK Inhibitor in Psoriatic Arthritis: A Case Report and Scoping Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-2281","authenticated-orcid":false,"given":"Mengduan","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9048-1831","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0022-1483","authenticated-orcid":false,"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-2389","authenticated-orcid":false,"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology First Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.596086"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S433367"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010022\u201000776\u20106"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30949-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30830-4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2024.2327589"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2023.105578"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102015\u2010208873"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)02263\u20103"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24025"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102020\u2010001450"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.032482"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.05.007"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20221"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055111"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40579"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1068"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key173"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.5070\/D31HD646HW"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110295"},{"issue":"10","key":"e_1_2_12_24_1","first-page":"1098","article-title":"Combination Use of Ustekinumab With Other Systemic Therapies: A Retrospective Study in a Tertiary Referral Center","volume":"12","author":"Heinecke G. 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