{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:56:07Z","timestamp":1790708167573,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["yyzdzk\u20102023111"],"award-info":[{"award-number":["yyzdzk\u20102023111"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["GJJ2400850"],"award-info":[{"award-number":["GJJ2400850"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This paper briefly reviews the structure, function, and activation mechanism of the NLRP3 inflammasome and its molecular role in the pathogenesis of knee osteoarthritis (KOA), and explores the potential value of traditional Chinese medicine (TCM) in treating KOA by modulating NLRP3 inflammasome activity. The review covers evidence from mechanistic studies, in vitro experiments, in vivo models, and currently available clinical\u2010related findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate the role of the NLRP3 inflammasome in KOA, a comprehensive literature search was conducted across multiple databases, including PubMed, MEDLINE, Web of Science, Scopus, and various Chinese biomedical repositories (CNKI, CBM, VIP, COJ). Emphasis was placed on studies published in the past 5 years concerning TCM\u2010based interventions targeting NLRP3 in KOA models, facilitating comparative analysis and synthesis of recent evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>NLRP3 inflammasome has been implicated in multiple pathological processes of KOA, including cartilage degradation, inflammation of the synovium, programmed cell death (pyroptosis), and the activation of osteoclasts. Interventions using TCM\u2014such as herbal monomers, multi\u2010compound formulas, external preparations, and acupuncture\u2014can mitigate these pathological events by modulating NLRP3 activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NLRP3 inflammasome is a critical mediator in KOA pathophysiology, influencing inflammation, cartilage deterioration, pyroptosis, and bone metabolism. Strategies derived from TCM that target this inflammasome may offer promising avenues for developing precise and effective treatments for KOA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70520","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:28:28Z","timestamp":1789986508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Knee Osteoarthritis Therapy Targeting NLRP3 Inflammasome: Progress From Mechanism to Application"],"prefix":"10.1002","volume":"14","author":[{"given":"Wenguang","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical Medical College of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-4540","authenticated-orcid":false,"given":"Baoxiu","family":"Yi","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziru","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-4688","authenticated-orcid":false,"given":"Zenan","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6504-9954","authenticated-orcid":false,"given":"Ensi","family":"Hong","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Jiangxi University of Chinese Medicine Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-024-10101-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703856114"},{"issue":"22","key":"e_1_2_10_4_1","first-page":"61","article-title":"Mechanism of Cangxitongbi Capsule Regulating Chondrocyte Pyroptosis Mediated by p38 MAPK\/NLRP3\/Caspase\u20101 Pathway in Knee Osteoarthritis","volume":"30","author":"Zhang Z. 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