{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:57:35Z","timestamp":1790708255408,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elderly atopic dermatitis (elderly AD) is increasingly recognized as a chronic inflammatory skin disorder with immunopathological features that may differ from those in younger populations. Age\u2010related chronic low\u2010grade inflammation (inflammaging) may contribute to this phenotype, but its relationship with immune dysfunction and disease chronicity remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review and meta\u2010analyze associations between inflammation\u2010related biomarkers and disease severity in older adults with AD and to organize the findings within a hypothesis\u2010generating conceptual framework of immune dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed and the China National Knowledge Infrastructure (CNKI) were searched from inception through December 15, 2025, without language restrictions. Reference lists of eligible reports were also screened. Two reviewers independently screened records, extracted data, and assessed methodological quality using the Joanna Briggs Institute critical appraisal checklist for analytical cross\u2010sectional studies. Correlation coefficients analyses were conducted in R version 4.4.1 using the metafor package, with manual calculations in Microsoft Excel. DerSimonian\u2010Laird random\u2010effects models were used when statistical or prespecified clinical or methodological heterogeneity made a common\u2010effect assumption inappropriate. Otherwise, fixed\u2010effect models were used. The findings were also organized descriptively into four proposed pathophysiological stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six studies met the inclusion criteria and were included for quantitative synthesis. A meta\u2010analysis revealed significant positive correlations between disease severity and serum total IgE, eosinophils, IL\u20104, and IL\u201017 levels. Among these biomarkers, eosinophil levels showed the most consistent association with disease severity across studies, whereas cytokines involved in Th2 and Th17 pathways showed considerable heterogeneity. Pathological stage\u2010oriented integration analysis provides a proposed conceptual model that an inflammaging\u2010related low\u2010grade inflammatory milieu may coexist with Th2\u2010polarized responses, aberrant Th17\u2010axis activation, impaired skin\u2010barrier repair, and AD persistence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older adults with AD may exhibit multidimensional immune dysregulation beyond a simple late\u2010life continuation of typical AD. Our findings support a hypothesis\u2010generating conceptual framework in which inflammaging is associated with Th2\u2010skewed responses, aberrant Th17 activation, and impaired skin\u2010barrier repair. This framework requires validation in prospective studies but may inform future personalized therapeutic research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70528","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:35:24Z","timestamp":1790699724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory Aging\u2010Driven Immune Axis Imbalance and the Mechanisms of Chronicity in Elderly Atopic Dermatitis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-8818","authenticated-orcid":false,"given":"Nan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing Jiaxing 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