{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:55:50Z","timestamp":1790708150954,"version":"4.1.0"},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic obstructive pulmonary disease (COPD) and atherosclerosis frequently coexist, but their shared immune mechanisms remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We integrated single\u2010cell RNA\u2010sequencing datasets from COPD lungs and atherosclerotic lesions to characterize immune\u2010cell composition, intercellular communication, and overlapping upregulated genes. Cell\u2010type\u2010specific sc\u2010eQTL data from oneK1K were further combined with FinnGen GWAS summary statistics for COPD and coronary atherosclerosis using Mendelian randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both diseases showed a macrophage\/monocyte\u2010centered immune architecture, with macrophages serving as major communication hubs. Among overlapping genes evaluated genetically, HSPA1B showed consistent associations across both diseases. Genetically predicted HSPA1B expression in classical monocytes was positively associated with COPD and coronary atherosclerosis, whereas expression in non\u2010classical monocytes showed inverse associations. NK cell\u2010specific HSPA1B expression was also positively associated with COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>COPD and atherosclerosis share myeloid\u2010centered immune features, and HSPA1B may represent a cell\u2010state\u2010dependent immune signal linking pulmonary and vascular inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70530","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:07:59Z","timestamp":1790669279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell\u2010Type\u2010Specific HSPA1B Expression Links COPD and Atherosclerosis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2026-8265","authenticated-orcid":false,"given":"Yangxin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzheng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8369-7485","authenticated-orcid":false,"given":"Houwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0336-0514","authenticated-orcid":false,"given":"You","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China"},{"name":"The Second Clinical Medical College of Zhejiang Chinese Medical University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"1","key":"e_1_2_1_7_2_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12951-026-04091-0","article-title":"COPD Airway Epithelial Cells\u2010Derived Extracellular Vesicles Contribute to Endothelial Dysfunction and Atherosclerosis via the miR\u2010141\u20103p\/PDCD4 Axis","volume":"24","author":"Wang Z.","year":"2026","journal-title":"Journal of Nanobiotechnology"},{"issue":"8","key":"e_1_2_1_7_3_1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/ATVBAHA.123.318926","article-title":"Cytokine\u2010Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge","volume":"43","author":"Schafer C. M.","year":"2023","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"11","key":"e_1_2_1_7_4_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41419-023-06318-6","article-title":"Caspase\u20108 Activation by Cigarette Smoke Induces Pro\u2010Inflammatory Cell Death of Human Macrophages Exposed to Lipopolysaccharide","volume":"14","author":"Cristaldi M.","year":"2023","journal-title":"Cell Death & Disease"},{"issue":"4","key":"e_1_2_1_7_5_1","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1161\/ATVBAHA.123.320524","article-title":"High\u2010Dimensional Single\u2010Cell Multimodal Landscape of Human Carotid Atherosclerosis","volume":"44","author":"Bashore A. C.","year":"2024","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"4","key":"e_1_2_1_7_6_1","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/hep.32444","article-title":"Single\u2010Cell Profiling of Human CD127+ Innate Lymphoid Cells Reveals Diverse Immune Phenotypes in Hepatocellular Carcinoma","volume":"76","author":"He Y.","year":"2022","journal-title":"Hepatology"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.70530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.70530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:56:07Z","timestamp":1790704567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.70530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/iid3.70530"],"URL":"https:\/\/doi.org\/10.1002\/iid3.70530","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70530"}}