{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:49:57Z","timestamp":1792162197438,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp; Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inhalant allergies from airborne allergens, such as pollen, dust mites, and animal dander, substantially contribute to allergic respiratory diseases globally. Sensitization to aeroallergens is influenced by environmental, urban, and climatic factors and demographic characteristics, including age and sex. However, long\u2010term data from large non\u2013disease\u2010specific patient cohorts in Jordan are unavailable, particularly those covering the COVID\u201019 pandemic years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize prevalence and patterns of aeroallergen\u2010specific IgE (s\u2010IgE) sensitization in Jordan over a 10\u2010year period (2012\u20132022), evaluating associations with age, sex, and temporal trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 4675 serum samples from patients tested at Biolab Diagnostic Laboratories. Aeroallergen s\u2010IgE was measured using the CE\u2010certified EUROLINE immunoblot panel covering 29 inhalant allergens. Samples positive for cross\u2010reactive carbohydrate determinants (2.4%) or repeat tests (3.8%) were excluded. Multivariable logistic regression assessed associations of sensitization with sex, age group (&lt;20, 20\u201340, &gt;40\u2009years), and sample collection period (2012\u20132015, 2016\u20132019, 2020\u20132022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 45.5% were sensitized to \u22651 aeroallergen. Males had higher odds of sensitization than females (OR\u2009=\u20091.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Sensitization was most prevalent in the 20\u201340\u2010year age group. Temporal analysis showed an increase in overall sensitization from 40% in 2012\u20132015 to 50.6% in 2020\u20132022. The most common sensitizers were predominantly pollens (olive pollen being the single most prevalent at 21.9%), along with cat dander (17.5%) and dust mites (~12% combined). A mixed pattern of increased sensitization to both outdoor and indoor aeroallergens was observed during the pandemic years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aeroallergen sensitization in Jordan shows significant sex\u2010, age\u2010, and time\u2010related patterns, with an overall increasing trend over the past decade, including during the COVID\u201019 pandemic. These findings provide a robust epidemiologic baseline to inform public health strategies, allergen mitigation, and clinical management in urban and regional contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.70533","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:27:08Z","timestamp":1791289628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Aeroallergen IgE Sensitization in Jordan: A Decade\u2010Long Observational Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Jumana","family":"Abu\u2010Kwaik","sequence":"first","affiliation":[{"name":"Department of Research and Development Biolab Diagnostic Laboratories Amman 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