{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:49:32Z","timestamp":1773337772741,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["#833247"],"award-info":[{"award-number":["#833247"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A major contributor to coronavirus disease 2019 (COVID\u201019) progression and severity is a dysregulated innate and adaptive immune response. Interleukin\u201038\u00a0(IL\u221238) is an IL\u20101 family member with broad anti\u2010inflammatory properties, but thus far little is known about its role in viral infections. Recent studies have shown inconsistent results, as one study finding an increase in circulating IL\u201038 in COVID\u201019 patients in comparison to healthy controls, whereas two other studies report no differences in IL\u201038 concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Here, we present an exploratory, retrospective cohort study of circulating IL\u201038 concentrations in hospitalized COVID\u201019 patients admitted to two Dutch hospitals (discovery\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009148 and validation\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009184) and age\u2010 and sex\u2010matched healthy subjects. Plasma IL\u201038 concentrations were measured by enzyme\u2010linked immunosorbent assay, disease\u2010related proteins by proximity extension assay, and clinical data were retrieved from hospital records.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201038 concentrations were stable during hospitalization and similar to those of healthy control subjects. IL\u201038 was not associated with rates of intensive care unit admission or mortality. Only in men in the discovery cohort, IL\u201038 concentrations were positively correlated with hospitalization duration. A positive correlation between IL\u201038 and the inflammatory biomarker\n                      <jats:sc>d<\/jats:sc>\n                      \u2010dimer was observed in men of the validation cohort. In women of the validation cohort,\u00a0IL\u201038 concentrations correlated negatively with thrombocyte numbers. Furthermore, plasma IL\u201038 concentrations in the validation cohort correlated positively with TNF, TNFRSF9, IL\u201010Ra, neurotrophil 3, polymeric immunoglobulin receptor, CHL1, CD244, superoxide dismutase 2, and fatty acid binding protein 2,\u00a0and negatively with SERPINA12 and cartilage oligomeric matrix protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data indicate that IL\u201038 is not associated with disease outcomes in hospitalized COVID\u201019 patients. However, moderate correlations between IL\u201038 concentrations and biomarkers of disease were identified in one of two cohorts. While we demonstrate that IL\u201038 concentrations are not indicative of COVID\u201019 severity, its anti\u2010inflammatory effects may reduce COVID\u201019 severity and should be experimentally investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.712","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T05:12:56Z","timestamp":1666761176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory analysis of interleukin\u201038 in hospitalized COVID\u201019 patients"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9198-7159","authenticated-orcid":false,"given":"Dennis M.","family":"de Graaf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboudumc Center for Infectious Diseases Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Department of Medicine University of Colorado Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa U.","family":"Teufel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboudumc Center for Infectious Diseases Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline H.","family":"de Nooijer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboudumc Center for Infectious Diseases Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan J.","family":"van Gammeren","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Hematology Amphia Hospital Breda The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonius A. 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