{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:13:58Z","timestamp":1762377238125,"version":"3.41.2"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Typically, Jaccoud arthropathy (JA) is characterized by joint deformation without bone erosion. However, some recent studies have shown that bone erosion also occurs in JA; however, this remains controversial. To date, there have been no unified diagnostic standards for JA. Herein, we report a case of systemic lupus erythematosus complicated with JA without bone erosion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 27\u2010year\u2010old woman was admitted to our department with a 2\u2010year history of pain, swelling, and progressive deformities of her hands and feet. She was diagnosed with systemic lupus erythematosus and class V lupus nephritis 5\u2009years prior. Upon examination, her erythrocyte sedimentation rate and C\u2010reactive protein levels were found to be increased. She was positive for antinuclear antibodies, antidouble stranded DNA antibodies, and antiextractable nuclear antigen antibodies, with a decreased complement C3 and C4. Radiography and magnetic resonance imaging revealed no bone erosion. The patient was diagnosed with JA. She was treated with oral prednisone (10\u2009mg daily), tofacitinib (5\u2009mg twice daily), methotrexate (10\u2009mg weekly), and celecoxib (0.2\u2009g twice daily).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patient's joint symptoms improved after treatment. No further progress was observed during the 4\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We believe that bone erosion is the key to distinguish rhupus syndrome from JA. However, this needs to be confirmed with further long\u2010term follow\u2010up studies. We found that the use tofacitinib, MTX, and celecoxib in combination with prednisone may be an effective regimen for the treatment of JA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.717","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T12:00:00Z","timestamp":1664366400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: Joint deformity associated with systemic lupus erythematosus"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0072-6277","authenticated-orcid":false,"given":"Shu\u2010Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"The First Clinical Medicine School Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Juan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"The First Clinical Medicine School Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"The First Clinical Medicine School Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"The First Clinical Medicine School Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Song","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"The First Clinical Medicine School Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"598","volume-title":"Sur une forme de rhumatisme chronique: lecions de clinique medicale faites a l'Hopital de la Charite","author":"Jaccoud FS","year":"1869"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa128"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/80.3.417"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05329-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000334"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2011.10.018"},{"issue":"3","key":"e_1_2_6_8_1","first-page":"273","article-title":"Jaccoud's arthropathy in adult dermatomyositis","volume":"4","author":"Bradley JD","year":"1986","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1017-1"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2016.01.007"},{"issue":"2","key":"e_1_2_6_11_1","first-page":"S102","article-title":"Jaccoud's arthropathy with vasculitis and primary Sj\u00f6gren's syndrome. 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