{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:02:29Z","timestamp":1792112549928,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE), especially neuropsychiatric SLE (NPSLE), is a complex systemic autoimmune disease, characterized by variable course and multiple organ dysfunction. Our study aimed to identify crucial microRNA (miRNAs) in SLE and NPSLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Totally 12 cases of serum specimens were collected from General Hospital of Ningxia Medical University (SLE\u2009=\u20094, NPSLE\u2009=\u20094, control\u2009=\u20094). After miRNA sequencing, differential expression analysis, miRNA target prediction, and miRNA\u2010messenger RNA (mRNA) regulatory network construction were performed to identify the hub miRNAs. The expression of target gene was determined by\u00a0quantitative reverse transcription\u2010polymerase chain reaction\u00a0and Western blot.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 79 and 59 differentially expressed miRNAs (DEmiRNAs) in NPSLE versus Control, and SLE versus Control, respectively. Among 35 overlapped DEmiRNAs, 5 upregulated miRNAs' (hsa\u2010miR\u2010762, hsa\u2010miR\u20104270, hsa\u2010miR\u20103663\u20103p, hsa\u2010miR\u20104778\u20105p, and hsa\u2010miR\u20104516) target genes were supported by at least six databases. The miRNA\u2010mRNA network indicated that core miRNA hsa\u2010miR\u2010762 regulated 1270 target genes. MiR\u2010762 was significantly upregulated in SLE and NPSLE, and over expression of miR\u2010762 significantly suppressed GIPC PDZ\u00a0domain containing family member 3 (GIPC3) expression in SLE and NPSLE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Upregulation of hub miRNA miR\u2010762 can suppress the expression of GIPC3 in both SLE and NPSLE samples, which is probably involved in the development of SLE and NPSLE. Meanwhile, along with the development from SLE to NPSLE, miR\u2010762 exhibits higher expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.719","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T12:06:30Z","timestamp":1665489990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Upregulation of microRNA\u2010762 suppresses the expression of GIPC3 in systemic lupus erythematosus and neuropsychiatric systemic lupus erythematosus"],"prefix":"10.1002","volume":"10","author":[{"given":"Jijuan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rheumatology General Hospital of Ningxia Medical University  Yinchuan Ningxia P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nursing Xingtai Medical College  Xingtai Hebei P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology General Hospital of Ningxia Medical University  Yinchuan Ningxia P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Emergency The First People's Hospital of Yinchuan  Yinchuan Ningxia P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Rheumatology General Hospital of Ningxia Medical University  Yinchuan Ningxia P.R.China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-2365","authenticated-orcid":false,"given":"Qikuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Physiology Ningxia Medical University  Yinchuan 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