{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:58:32Z","timestamp":1779303512659,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Systematic literature was conducted in PubMed, Embase, Google Scholar, and Scopus using predefined MESH terms by using \u201cAND\u201d and \u201cOR.\u201d The following search terms were used: Monkeypox [MeSH] OR \u201cMonkeypox virus\u201d [MeSH] OR \u201cPOX\u201d OR \u201cMonkeypox\u201d AND \u201cOutbreak\u201d AND \u201cOutcomes\u201d from December 2019 till 14th June 2022 without restrictions of language.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1074 (99.90%) patients tested positive for Monkeypox virus through RT\u2010PCR while 1 (0.09) patient was suspected. There was a gender difference with male predominance (54.23% vs. 45.48%) compared with female patients. Mean age (\u00b1\n                      <jats:italic>SD<\/jats:italic>\n                      ) of patients was 20.66\u2009\u00b1\u200916.45 years. The major symptoms were rash (100%), fever (96%), and other important symptoms were upper respiratory symptoms (97%), headache (95%), vomiting (95%), oral ulcers (96%), conjunctivitis (96%) and lymphadenopathy (85%). The average mean duration of treatment was 5 days, while the mean hospitalization duration was 13.3\u2009\u00b1\u20096.37 days. The outcome of 20 patients was available, 19 of 20 patients recovered fully from monkeypox, however, 1 patient was not able to survive resulting in death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The recent monkeypox virus outbreak has shown that the virus could transmit in ways that were not previously expected. Further research is needed to understand the possible outcomes and association with humans and their different organ systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.722","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T12:07:33Z","timestamp":1665490053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID\u201019 era: A systematic\u2010review"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2021-1660","authenticated-orcid":false,"given":"Vikash","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Research Larkin Community Hospital South Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanshu","family":"Nain","sequence":"additional","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-3843","authenticated-orcid":false,"given":"Dattatreya","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Medicine Raiganj Government Medical College and Hospital Raiganj West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amey","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Research Larkin Community Hospital South Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-6544","authenticated-orcid":false,"given":"Mittal","family":"Savaliya","sequence":"additional","affiliation":[{"name":"Department of Medicine GMERS Medical College Junagadh Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6789-5860","authenticated-orcid":false,"given":"Angela","family":"Ishak","sequence":"additional","affiliation":[{"name":"Department of Research Larkin Community Hospital South Miami Fl USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitya","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipansha","family":"Maroo","sequence":"additional","affiliation":[{"name":"Department of Medicine Maulana Azad Medical College New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Medicine Janaki Medical College Dhanusha Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization. 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