{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:56:19Z","timestamp":1791867379920,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Circular RNAs (circRNAs) are a new category of endogenous non\u2010protein coding RNAs (ncRNAs), and show the characteristics of high conservation, stability, and tissue specificity. Due to rapid advances in next\u2010generation sequencing and transcriptome profiling technologies, circRNAs have been widely discovered in many organisms and participated in the development and progress of a variety of diseases. As a type of molecular sponge, circRNAs mainly absorb micro RNAs competitively and interplay with RNA\u2010binding proteins to modulate the splicing as well as transcription of target genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This review is based on a literature search using the Medline database. Search terms used were \u201ccircular RNAs and leukemia,\u201d \u201ccircRNAs and leukemia,\u201d \u201ccircRNAs and acute lymphoblastic leukemia,\u201d \u201ccircRNAs and chronic lymphoblastic leukemia,\u201d \u201ccircRNAs and acute myeloid leukemia,\u201d \u201ccircRNAs and chronic myeloid leukemia,\u201d and \u201ccircRNAs, biomarker, and hematological system.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CircRNAs have been proven as potential biomarkers and therapeutic targets in a variety of tumors. Recent research has found that circRNAs aberrantly exist in hematological cancers, especially leukemia, and are significantly associated with the incidence, progress, and metastasis of diseases as well as the prognosis of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current work summarizes the latest findings on circRNAs in various types of leukemia, aiming to propose prospective therapies and new drug screening methods for the treatment of leukemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.725","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T07:18:12Z","timestamp":1672384692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Emerging roles of circRNAs in leukemia and the clinical prospects: An update"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-3993","authenticated-orcid":false,"given":"Wei","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Pediatric General Internal Medicine Gansu Provincial Maternity and Child\u2010Care Hospital  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Internal Medicine Gansu Provincial Maternity and Child\u2010Care Hospital  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Internal Medicine Gansu Provincial Maternity and Child\u2010Care Hospital  Lanzhou City Gansu Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447076"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-018-2412-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000855"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-000-0105-x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2022.2064742"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.912303"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2RU0619-213R"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1069-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00359-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-1426-1_4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1020271"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092622"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2089-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1120-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00976-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1669924"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-022-02013-x"},{"key":"e_1_2_10_20_1","article-title":"Whole transcriptome analysis of platelet concentrates during storage","author":"Heililahong H","year":"2022","journal-title":"Blood Transfus"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-649434"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50864-z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.786224"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-022-00375-3"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.10"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25975"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871529X18666180515130136"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.020"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000802"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01395-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003230"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2829"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"155","article-title":"The PML\/RAR alpha fusion gene in the diagnosis and monitoring of acute promyelocytic leukemia","volume":"80","author":"Diverio D","year":"1995","journal-title":"Haematologica"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00514-3"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0699-2"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25011"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100825"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0776-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1567"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1957749"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00109"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.728916"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2018_181129N908"},{"key":"e_1_2_10_44_1","article-title":"circ_0080145 enhances imatinib resistance of chronic myeloid leukemia by regulating miR\u2010326\/PPFIA1 axis","author":"Che H","year":"2020","journal-title":"Cancer Biother Radiopharm"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12927"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.04.003"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.639910"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144726"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1997197"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.2008590"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153536"},{"issue":"11","key":"e_1_2_10_52_1","article-title":"Regulation effects of circular RNA CircPVT1 and miR\u2010125b on NF\u2010\u03baB signal pathway in childhood ALL","volume":"67","author":"Jia Y","year":"2021","journal-title":"Clin Lab"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01655"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002337"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.09.003"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26367"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2020.04.001"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101997"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0594-6"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.045"},{"key":"e_1_2_10_61_1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2855394","article-title":"circZNF91 promotes the malignant phenotype of chronic lymphocytic leukemia cells by targeting the miR\u20101283\/WEE1 axis","volume":"2022","author":"Li S","year":"2022","journal-title":"BioMed Res Int"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.04.017"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0108-6"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.725","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T16:09:32Z","timestamp":1743869372000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/iid3.725"],"URL":"https:\/\/doi.org\/10.1002\/iid3.725","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e725"}}