{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:51:07Z","timestamp":1773337867046,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>C. pneumoniae<\/jats:italic>\n                    ) is a gram\u2010negative intracellular bacterium that causes respiratory infection in humans, including subjects with or without asthma.\n                    <jats:italic>C. pneumoniae<\/jats:italic>\n                    activates cells (e.g., monocytes\/macrophages) in vitro, and produces cytokines that may contribute to inflammatory responses observed in asthma. Immunological differences exist between subjects with or without asthma, with regard to host responses to\n                    <jats:italic>C. pneumoniae<\/jats:italic>\n                    . The heterogeneity and subsequent diverse pathophysiology of asthma can be better understood by analyzing the repertoire of T\u2010cell subpopulations; the most common distinction between different asthma endotypes includes cytokines produced by CD4\n                    <jats:sup>+<\/jats:sup>\n                    \u00a0cells (T helper (Th)2 high vs. Th2 low).\n                  <\/jats:p>","DOI":"10.1002\/iid3.726","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T08:37:28Z","timestamp":1666859848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CD4\n                    <sup>+<\/sup>\n                    T effector memory cell responses in\n                    <i>Chlamydia pneumoniae<\/i>\n                    \u2010stimulated peripheral blood mononuclear cells in nonasthmatic subjects"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-6728","authenticated-orcid":false,"given":"Tamar A.","family":"Smith\u2010Norowitz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases State University of New York Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Shidid","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases State University of New York Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yitzchok M.","family":"Norowitz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases State University of New York Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Kohlhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases State University of New York Downstate Health Sciences University Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2174","volume-title":"Principles and Practice of Infectious Diseases","author":"Hammerschlag MR","year":"2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1743PP"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1994.02170070065013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.1.178"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113563"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.999041"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.02.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.23822\/EurAnnACI.1764-1489.177"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12561"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00209-09"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S303275"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700911"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00395.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2407"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:13:34Z","timestamp":1773299614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/iid3.726"],"URL":"https:\/\/doi.org\/10.1002\/iid3.726","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"2022-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e726"}}