{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:34:15Z","timestamp":1775756055478,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periodontitis is a common oral inflammatory disease, and lipopolysaccharide (LPS) is a key risk factor in periodontitis pathology. Here, we used LPS\u2010induced periodontal ligament cells (PDLCs) to explore the molecular mechanism of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cell viability, proliferation, and apoptosis were analyzed by Cell Counting Kit\u20108, 5\u2010ethynyl\u201020\u2010deoxyuridine (EDU), and flow cytometry assays, respectively. Apart from that, their targeting relationship was validated using dual\u2010luciferase reporter and RNA\u2010pull down.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circular RNA_0138960 (circ_0138960) was notably upregulated in periodontitis sufferers (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and LPS\u2010disposed PDLCs (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). LPS exposure dampened PDLC proliferation, and promoted apoptosis and inflammation (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Circ_0138960 acted as a microRNA\u00a0sponge for miR\u2010518a\u20105p to affect histone deacetylase 6 (HDAC6) expression. Circ_0138960 absence\u2010mediated protective effects in LPS\u2010induced PDLCs were largely abrogated via silencing miR\u2010518a\u20105p or HDAC6 overexpression (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circ_0138960 promoted LPS\u2010induced dysfunction in PDLCs by targeting miR\u2010518a\u20105p\/HDAC6 axis, which provided novel potential therapeutic targets for periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.732","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T14:19:25Z","timestamp":1667830765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circ_0138960 contributes to lipopolysaccharide\u2010induced periodontal ligament cell dysfunction"],"prefix":"10.1002","volume":"10","author":[{"given":"Shuangshuang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology Dongying Shengli Oilfield Central Hospital Dongying City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-0240","authenticated-orcid":false,"given":"Huilin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dongying Shengli Oilfield Central Hospital Dongying City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dongying Shengli Oilfield Central Hospital Dongying City Shandong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-3120","authenticated-orcid":false,"given":"Ruijing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Dongying Shengli Oilfield Central Hospital Dongying City Shandong Province 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