{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:16:51Z","timestamp":1790713011497,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to investigate the effect of etanercept in psoriasis and its underlying mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Female mice were treated with imiquimod (IMQ) to induce psoriasis, and intraperitoneally administered etanercept (0.1\u20130.4\u2009mg\/ml). The RAW264.7 cells were treated with LPS and IFN\u2010\u03b3 to polarize to M1, and were treated with IL\u201013 and IL\u20104 to polarize to M2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our study, Etanercept markedly reduced the psoriasis area and severity index\u00a0scores, and epidermal thickness of mice induced by IMQ. In addition, etanercept reduced the levels of TNF\u2010\u03b1 and IL\u20106\/12\/23, and enhanced the levels of IL\u20104\/10, reduced Th17\/Treg ratio and facilitated the polarization of macrophages to M2 in psoriasis model mice. Furthermore, etanercept inhibited the JAK\/STAT3 pathway and increased the protein levels of SOCS1 and SOCS3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, our findings indicated that etanercept could inhibit the JAK\/STAT3 pathway to reduce Th17\/Treg ratio and promote M2 polarization, thereby alleviating psoriasis of mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.734","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T09:21:53Z","timestamp":1667812913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Etanercept alleviates psoriasis by reducing the Th17\/Treg ratio and promoting M2 polarization of macrophages"],"prefix":"10.1002","volume":"10","author":[{"given":"Xiaoqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Huaian No.1 Peoples Hospital of Nanjing Medical University  Huai'an Jiangsu P.R. 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