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Researchers believe that increasing knowledge about the function of MQs in inflammatory disorders plays a critical role in finding a new treatment for these kinds of diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main body<\/jats:title><jats:p>CD is a permanent autoimmune intestinal disorder triggered by gluten exposure in predisposed individuals. This disorder happens due to the loss of intestinal epithelial barrier integrity characterized by dysregulated innate and adaptive immune responses. MQs are known as key players of the innate immune system that link innate and adaptive immunity. MQs of human intestinal lamina propria participate in maintaining tissue homeostasis, and also intestinal inflammation development. Previous studies suggested that gliadin triggers a proinflammatory phenotype (M1 MQ) in human primary MQs. Moreover, M2\u2010related immunosuppressive mediators are also present in CD. In fact, CD patients present an impaired transition from pro\u2010inflammatory to anti\u2010inflammatory responses due to inappropriate responses to gliadin peptides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The M1\/M2 MQs polarization balancing regulators can be considered novel therapeutic targets for celiac disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.741","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T08:13:10Z","timestamp":1668586390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The modulation of macrophage subsets in celiac disease pathogenesis"],"prefix":"10.1002","volume":"10","author":[{"given":"Sara","family":"Molaaghaee\u2010Rouzbahani","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine Shahid Beheshti University of Medical Sciences  Tehran 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