{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:19:18Z","timestamp":1789330758423,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic periodontitis (CP) is an inflammatory periodontal disease with high incidence and complex pathology. This research is aimed to investigate the function of exosomal miR\u2010205\u20105p (Exo\u2010miR\u2010205\u20105p) in CP and the underlying molecular mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Exo\u2010miR\u2010205\u20105p was isolated from miR\u2010205\u20105p mimics\u2010transfected periodontal ligament stem cells (PDLSCs), and subsequently cocultured with lipopolysaccharide (LPS)\u2010induced cells or injected into LPS\u2010treated rats. The mRNA expression of inflammatory factors and Th17\/Treg\u2010related factors were measured by quantitative real\u2010time PCR. The contents of inflammatory factors and the percentages of Th17\/Treg cells were measured by enzyme\u2010linked immunosorbent assay\u00a0and flow cytometry, respectively. Besides, the target relation between miR\u2010205\u20105p and X\u2010box binding protein 1 (XBP1) was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MiR\u2010205\u20105p was downregulated in LPS\u2010induced PDLSCs and corresponding exosomes. Exo\u2010miR\u2010205\u20105p inhibited inflammatory cell infiltration, decreased the production of TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106, and decreased the percentage of Th17 cells in LPS\u2010treated rats. In addition, XBP1 was a target of miR\u2010205\u20105p. Overexpression of XBP1 weakened the effects of Exo\u2010miR\u2010205\u20105p on inhibiting inflammation and regulating Treg\/Th17 balance in LPS\u2010induced cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Exo\u2010miR\u2010205\u20105p derived from PDLSCs relieves the inflammation and balances the Th17\/Treg cells in CP through targeting XBP1.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.743","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T08:53:25Z","timestamp":1671440005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Exosomal miR\u2010205\u20105p derived from periodontal ligament stem cells attenuates the inflammation of chronic periodontitis via targeting XBP1"],"prefix":"10.1002","volume":"11","author":[{"given":"Lixun","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Stomatology, Shengjing Hospital China Medical University  Shenyang City Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Shengjing Hospital China Medical University  Shenyang City Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Shengjing Hospital China Medical University  Shenyang City Liaoning Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Shengjing Hospital China Medical University  Shenyang City Liaoning Province 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