{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:07:11Z","timestamp":1768612031668,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic>\u00a0is planted in the human stomach and is the most common cause of chronic gastritis, which produced specific local and systemic humoral immunity, while the associations of these immune responses and <jats:italic>H. pylori<\/jats:italic> in the development of chronic gastritis remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzed histology, the number of Th22 and regulatory T (Treg) cells, and the levels of inflammation\u2010 and gastritis\u2010related indicators between 22 <jats:italic>H. pylori<\/jats:italic>\u2010infected and 24 non\u2010<jats:italic>H. pylori<\/jats:italic>\u2010infected chronic gastritis patients by hematoxylin\u2010eosin\u00a0staining, enzyme\u2010linked immunosorbent assay, quantitative reverse transcription PCR, and flow cytometry analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study found that the pathological damage degree of gastric mucosa in <jats:italic>H. pylori<\/jats:italic> infection patients was more serious. In the <jats:italic>H. pylori<\/jats:italic>\u2010infected patient serum, the gastrin, G\u201017, interleukins\u00a0(IL)\u201022, transforming growth factor\u00a0(TGF)\u2010\u03b2, tumor necrosis factor\u00a0(TNF)\u2010\u03b1, IL\u20104, and IL\u201017A levels were notably raised, while the interferon\u00a0(IFN)\u2010\u03b3 level was inhibited, and in gastric mucosa, and except IFN\u2010\u03b3, the IL\u201022, forkhead box P3 (Foxp3), TNF\u2010\u03b1, IL\u20104, and IL\u201017A mRNA levels were raised too. The receiver operating characteristic\u00a0curve analysis indicates serum IL\u201022, TGF\u2010\u03b2, TNF\u2010\u03b1, IL\u20104, and IL\u201017A are suitable for differential diagnosis of <jats:italic>H. pylori<\/jats:italic> infection. In addition, in the peripheral blood, the percentages of the IL\u201022<jats:sup>+<\/jats:sup> CD4<jats:sup>+<\/jats:sup> and Foxp3<jats:sup>+<\/jats:sup> CD4<jats:sup>+<\/jats:sup> T cells were raised with <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection. The positive correlation between IL\u201022 and Foxp3 mRNA levels and the degree of <jats:italic>H. pylori<\/jats:italic> colonization and gastric mucositis by Pearson's\u00a0correlation analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treg and Th22 cells were positively associated with the degree of <jats:italic>H. pylori<\/jats:italic> infection and the severity of gastritis. In summary, this study provides an experimental basis for the study of the eradication of <jats:italic>H. pylori<\/jats:italic> and the biological mechanism of chronic gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.768","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T08:27:19Z","timestamp":1674030439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The correlation of Th22 and regulatory T cells with <i>Helicobacter pylori<\/i> infection in patients with chronic gastritis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7381-6137","authenticated-orcid":false,"given":"Biyu","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology People's Hospital of Yuhuan Zhejiang Taizhou 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