{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:10:44Z","timestamp":1778821844164,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to explore the clinical characteristics in chronic rhinosinusitis with nasal polyps (CRSwNP) patients with different serum specific IgE (SIgE) and eosinophilic granulocyte infiltration status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study included patients diagnosed with CRSwNP and underwent functional endoscopic sinus surgery at the Yinchuan First People's Hospital between June 2019 and June 2021. A total of 192 patients with CRSwNP were included (100 males). The patients were 41.7\u2009\u00b1\u200915.1 years old. The disease course ranged 4.6\u201318.2 months. The visual analog scale (VAS) score (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), endoscopic score (<jats:italic>p<\/jats:italic>\u2009=\u2009.014), computerized tomography (CT) score (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.00) and the sino\u2010nasal outcome Test\u201022 (SNOT\u201022) score (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were significantly different among patients with SIgE\u2010positive combined eosinophilic chronic rhinosinusitis (ECRS), patients with SIgE\u2010positive combined non\u2010ECRS, patients with SIgE\u2010negative combined ECRS, and patients with SIgE\u2010negative combined non\u2010ECRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In pairwise comparison, the VAS score (20.72\u2009\u00b1\u20092.24 vs. 13.09\u2009\u00b1\u20091.62, 13.84\u2009\u00b1\u20091.34, and 12.67\u2009\u00b1\u20091.20, respectively), endoscopic score (8.09\u2009\u00b1\u20091.04 vs. 7.06\u2009\u00b1\u20090.98, 7.69\u2009\u00b1\u20091.18, and 7.75\u2009\u00b1\u20091.07, respectively), CT score (13.18\u2009\u00b1\u20091.66 vs. 8.79\u2009\u00b1\u20090.88, 11.08\u2009\u00b1\u20091.12, and 11.08\u2009\u00b1\u20091.12, respectively), and SNOT\u201022 score (27.62\u2009\u00b1\u20092.31 vs. 12.09\u2009\u00b1\u20091.83, 14.84\u2009\u00b1\u20091.84, and 12.97\u2009\u00b1\u20091.50, respectively) was significantly higher in patients with SIgE\u2010positive combined ECRS compared to patients with SIgE\u2010positive combined non\u2010ECRS, patients with SIgE\u2010positive combined non\u2010ECRS (all <jats:italic>p<\/jats:italic> &lt; .0083). The VAS score, endoscopic score, and CT score might be higher in CRSwNP patients with SIgE\u2010positive combined ECRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, the VAS score, endoscopic score, and CT score were higher in the patients with SIgE\u2010positive combined ECRS. This study might provide a reference for treatment in patients with CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.773","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T12:04:41Z","timestamp":1676549081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative study of clinical symptoms of chronic rhinosinusitis with nasal polyps patients"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1457-8092","authenticated-orcid":false,"given":"Jingmin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of ENT The First Hospital of Yinchuan Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of ENT The First Hospital of Yinchuan Yinchuan 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