{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:38:39Z","timestamp":1788212319926,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this cross\u2010sectional study was to compare the levels of inflammatory mediators in nasal secretions in patients with aspirin\u2010exacerbated respiratory disease (AERD) and in those with nasal polyposis (NP) without aspirin\u2010sensitivity and to correlate nasal fluid mediator concentrations with clinical parameters of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 patients with AERD, 30 chronic rhinosinusitis (CRS) with NP patients without aspirin sensitivity (CRSwNP), and 30 control subjects without inflammation of the nasal mucosa (C), selected for surgical treatment entered the study. The total nasal symptom score (TNSS), endoscopic score (ES), and Lund\u2010Mackay score (LMS), were evaluated. The concentrations of eosinophil cationic protein (ECP), tryptase, heat shock protein 70 (HSP70), substance P and Clara cell protein 16 (CC16) were determined in nasal secretions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher concentrations of ECP, tryptase, and HSP70 were measured in the AERD patients than in the CRSwNP patients and the C group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, respectively for all mediators). However, levels of CC16 were higher in the C group than in the AERD and CRSwNP groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001, respectively). A positive correlation between the TNSS and CC16 and a negative one between CC16 and tryptase levels were found in the C group. The CRSwNP group showed positive correlations between ECP, HSP70, and tryptase and negative correlations between substance P, ES, and LMS, as well as between CC16 and tryptase levels. In the AERD group, we found a positive correlation between HSP70 and ECP levels and a negative correlation between the TNSS and CC16 concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The obtained results indicate the increased production of mediators of eosinophil and mast cell function, and the decreased production of biomarker of respiratory epithelial function in AERD patients. Clinical and biochemical parameters correlate in different ways in the AERD and CRSwNP patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.791","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T08:40:20Z","timestamp":1677141620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inflammatory mediators in nasal secretions of patients with nasal polyposis with and without aspirin sensitivity"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8453-7272","authenticated-orcid":false,"given":"Aleksandar","family":"Peri\u0107","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy University of Defence  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Ga\u0107e\u0161a","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology ENT Hospital \u201eDr. \u017duti\u0107\u201c  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Cvetkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Faculty of Medicine of the Military Medical Academy University of Defence  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Vojvodi\u0107","sequence":"additional","affiliation":[{"name":"Division of Clinical and Experimental Immunology, Faculty of Medicine of the Military Medical Academy Institute for Medical Research  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"issue":"29","key":"e_1_2_10_2_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens WJ","year":"2020","journal-title":"Rhinology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22741"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2016.7.0149"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4259"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03118.x"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"215","article-title":"Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants","volume":"69","author":"Peri\u0107 A","year":"2018","journal-title":"Arch Ind Hyg Toxicol"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"901","article-title":"Neurohormonal markers in chronic rhinosinusitis","volume":"35","author":"Compton RA","year":"2021","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X19875076"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.387"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13599"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01305.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900060037006"},{"issue":"4","key":"e_1_2_10_17_1","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund VJ","year":"1993","journal-title":"Rhinology"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21710"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01989.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053811"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino.11.152"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22073_c"},{"issue":"3","key":"e_1_2_10_23_1","first-page":"214","article-title":"Effect of fluticasone on neuropeptides in nasal lavage in persistent allergic rhinitis","volume":"20","author":"Sch\u00e4per C","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.347"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3182857d6c"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2278OC"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9923-0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200201000-00010"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin08.109"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21546"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065898782103025"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276842"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1994.tb01231.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2017.17203"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iid3.791","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T11:48:51Z","timestamp":1692445731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/iid3.791"],"URL":"https:\/\/doi.org\/10.1002\/iid3.791","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"value":"2050-4527","type":"print"},{"value":"2050-4527","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e791"}}