{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:07:53Z","timestamp":1788617273628,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiopulmonary bypass may cause malfunction in the myocardium. Cuproptosis is a novel cell death aggregating mitochondrial proteins. However, the research on cardiopulmonary bypass\u2010caused heart tissue injury in immune infiltration and cuproptosis is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Immune infiltration, enrichment analysis, protein\u2212protein interaction network, and medication prediction are applied to reanalysis differentially expressed genes and cuproptosis\u2010related genes in gene expression omnibus\u00a0data set GSE132176.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven cuproptosis related genes (PDHA1, LIPT1, LIAS, DLST, DLD, DLAT, and DBT) and dendritic cells and Th1 cells are involved in heart tissue injury in response to surgery with cardiopulmonary bypass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immune infiltration and cuproptosis are potential mechanisms by which cardiopulmonary bypass surgery may cause damage to heart tissue, which may be a new therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.795","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T14:32:15Z","timestamp":1678804335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The potential value of cuprotosis in myocardial immune infiltration that occurs in pediatric congenital heart disease in response to surgery with cardiopulmonary bypass"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2855-3737","authenticated-orcid":false,"given":"Song","family":"Puwei","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Siyu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Children's Hospital of Nanjing Medical University Nanjing 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