{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:05:48Z","timestamp":1790809548268,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2022GXNSFAA035498"],"award-info":[{"award-number":["2022GXNSFAA035498"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis (PsO) is a T\u2010cell\u2010associated inflammatory autoimmune dermatitis. Leucine leucine\u201037 (LL\u201037) is upregulated in PsO patients and correlated with the area and severity of PsO. However, the exact relation between LL\u201037 and T cell\u2010associated inflammation is not well understood. It is very important to clarify the relationship between LL\u201037 and inflammatory response for clinical diagnosis and treatment of PsO. This study investigated the serum levels of LL\u201037 and inflammatory cytokines, as well as correlations between them in PsO patients, which aimed to provide new ideas for the diagnosis and treatment of PsO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PsO patients (<jats:italic>n<\/jats:italic>\u2009=\u200950) and healthy volunteers (<jats:italic>n<\/jats:italic>\u2009=\u200933) were recruited in this study. Skin specimens were stained with hematoxylin and eosin (H&amp;E). The serum levels of LL\u201037, T\u2010helper type 1 (Th1, IFN\u2010\u03b3), T\u2010helper type 17 (Th17, IL\u201017), T\u2010helper type 22 (Th22, IL\u201022), and T\u2010helper type 2 cytokines (Th2, IL\u20104) were assessed by enzyme\u2010linked immunosorbent assay. Some of the patients were re\u2010recruited after treatment to evaluate LL\u201037 and cytokines levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pathological changes were observed in PsO\u00a0skin lesions. LL\u201037, IFN\u2010\u03b3, IL\u201017, and IL\u201022 serum levels were much higher in PsO patients than those in healthy volunteers (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and posttreatment reduction was observed in five patients. However, no remarkable difference in IL\u20104 level (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05) was found. LL\u201037 level was positively correlated with IFN\u2010\u03b3, IL\u201017, and IL\u201022 levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in PsO patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LL\u201037 expression was significantly associated with inflammatory response, which may provide us new ideas for diagnosing and monitoring disease activity of PsO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.802","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T14:30:52Z","timestamp":1678804252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Serum LL\u201037 and inflammatory cytokines levels in psoriasis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1996-6484","authenticated-orcid":false,"given":"Juanfeng","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Laboratory 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