{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:33:21Z","timestamp":1778589201628,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) causes coronavirus disease 2019 (COVID\u201019) with significant morbidity and mortality. We reported and compared the clinical and para\u2010clinical findings of immunocompromised and immunocompetent COVID\u201019 patients in a case\u2010control study at the Imam Khomeini hospital in Tehran, Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 107 immunocompromised COVID\u201019 patients were recruited as the case group, and 107 immunocompetent COVID\u201019 patients as the control group. The participants were matched based on age and sex. The patients' information was retrieved from the hospital records in an information sheet. Associations between clinical and para\u2010clinical findings with the immune status were assessed using bivariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial pulse rate and recovery time were significantly higher in immunocompromised patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Myalgia, nausea\/vomiting, loss of appetite, headache, and dizziness were more frequently reported by the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Regarding the prescribed medications' duration, Sofosbovir was used longer in the case group, while Ribavirin was used longer in the control groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The most common complication in the case group was acute respiratory distress syndrome, although no major complications were observed in the control group. According to the multivariate analysis, recovery time and Lopinavir\/Ritonavir (Kaletra) prescription were significantly higher in the immunocompromised compared to the immunocompetent group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recovery time was significantly longer in the immunocompromised compared to the immunocompetent group, which emphasizes the necessity of prolonged care in these high\u2010risk patients. Also, it is recommended to investigate the effect of novel therapeutic interventions to reduce the recovery time in addition to improving the prognosis of immunodeficient patients with COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.806","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T09:30:34Z","timestamp":1681291834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The comparison of clinical, laboratory, and radiological findings in immunocompromised and immunocompetent patients with COVID\u201019: A case\u2010control study"],"prefix":"10.1002","volume":"11","author":[{"given":"Ladan","family":"Abasian","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran 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