{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:16:37Z","timestamp":1784646997460,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study determined the therapeutic effect of ulinastatin (UTI) on unliquefied pyogenic liver abscesses complicated by septic shock (UPLA\u2010SS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized controlled trial involving patients with UPLA\u2010SS who underwent treatment at our hospital between March 2018 and March 2022. The patients were randomly divided into control (<jats:italic>n<\/jats:italic>\u2009=\u200951) and study groups (<jats:italic>n<\/jats:italic>\u2009=\u200948). Both groups received routine treatment, but the study group received UTI (200,000 units q8h for &gt;3 days). Differences in liver function, inflammatory indices, and effectiveness between the two groups were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following treatment, the white blood cell count, and lactate, C\u2010reactive protein, procalcitonin, tumor necrosis factor\u2010\u03b1, and interleukin\u20106 levels were significantly decreased in all patients compared to the admission values (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The study group had a faster decline with respect to the above indices compared to the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The study group length of intensive care unit\u00a0stay, fever duration, and vasoactive drug maintenance time were all significantly shorter than the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The total bilirubin, alanine aminotransferase, and aspartate aminotransferase levels were significantly lower in the study and control groups after treatment compared to before treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05); however, the study group had a faster recovery of liver function than the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The overall mortality rate was 14.14% (14\/99); 10.41% of the study group patients died and 17.65% of the control group patients died, but there was no statistically significant difference between the two groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>UTI combined with conventional treatment significantly controlled the infection symptoms, improved organ function, and shortened the treatment time in patients with UPLA\u2010SS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.822","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T13:11:14Z","timestamp":1681737074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical efficacy of ulinastatin in the treatment of unliquefied pyogenic liver abscess complicated by septic shock: A randomized controlled trial"],"prefix":"10.1002","volume":"11","author":[{"given":"Mingfeng","family":"Guo","sequence":"first","affiliation":[{"name":"Department of ICU The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University  Huai'an Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-1190","authenticated-orcid":false,"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University  Huai'an Jiangsu P. R. 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