{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:24:07Z","timestamp":1783441447949,"version":"3.54.6"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study mainly observes changes in perioperative mineral bone metabolism\u2010related indicators and inflammatory factors in patients with secondary hyperparathyroidism (SHPT), and analyzed the correlation between mineral bone metabolism\u2010related indicators and inflammatory factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data were collected. The study detects mineral bone metabolism\u2010related indicators and inflammatory factor of perioperative patients with SHPT before and 4 days after operation. The production of high\u2010sensitivity c\u2010reactive protein (hs\u2010CRP) in human hepatocytes cells (LO2 cells) stimulated by different concentrations of parathyroid hormone\u2010associated protein was detected by enzyme\u2010linked immunosorbent assay, reverse\u2010transcription polymerase chain reaction\u00a0(RT\u2010PCR), and western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of mineral bone metabolism\u2010related indicators and hs\u2010CRP in SHPT group were significantly higher than those of control group. After operation, serum calcium, serum phosphorus, iPTH, FGF\u201023 decreased, and the level of osteoblast active biomarkers increased, while the level of osteoclast active biomarkers decreased. The levels of hs\u2010CRP decreased significantly after operation. With the increase of PTHrP concentration, hs\u2010CRP level in supernatant of LO2 cells decreased first and then increased. RT\u2010PCR and western blot shows the same trend.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parathyroidectomy can significantly improve bone resorption and inflammation in SHPT patients. We speculate that there may be an optimal range of PTH concentrations to minimize inflammation in the body.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.828","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T09:35:51Z","timestamp":1681292151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period"],"prefix":"10.1002","volume":"11","author":[{"given":"Lei","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou 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