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However, it is now confirmed that they are ubiquitously expressed in cells within the body including neurons, astrocytes, and microglia of the central nervous system (CNS). Activation of TLRs is capable of inducing immunologic and inflammatory responses to injury or infection of CNS. This response is self\u2010limiting that usually resolves once the infection has been eradicated or the tissue damage has been repaired. However, the persistence of inflammation\u2010inducing insults or a failure in normal resolution mechanisms may result in overwhelming inflammation which may induce neurodegeneration. This implies that TLRs may play a role in mediating the link between inflammation and neurodegenerative diseases namely Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, and amyotrophic lateral sclerosis. So, new therapeutic approaches that specifically target TLRs may be developed by better understanding TLR expression mechanisms in the CNS and their connections to particular neurodegenerative disorders. Therefore, this review paper discussed the role of TLRs in neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/iid3.839","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T09:45:12Z","timestamp":1681897512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Toll\u2010like receptors in pathogenesis of neurodegenerative diseases and their therapeutic potential"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-5726","authenticated-orcid":false,"given":"Yosef Tsegaye","family":"Dabi","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, Institute of Health Sciences Wollega University Nekemte Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abayomi O.","family":"Ajagbe","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Health Sciences,\u00a0Faculty of 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