{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T17:07:24Z","timestamp":1775668044877,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To reveal the relationship between the fibulin\u20102 protein and immune dysfunction after bone trauma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals who were admitted to the study were divided into a bone trauma group, a recovered from bone trauma group and a volunteer without bone trauma group based on the reason for admission. Fibulin\u20102 levels in the three groups were compared. <jats:italic>Fibulin\u20102<\/jats:italic>\u2010knockout (<jats:italic>fibulin\u20102<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) mice and wild\u2010type (WT) mice were used to detect susceptibility to infection. Hematoxylin and eosin (HE) staining and immunohistochemical staining were employed to observe pathological changes in each organ from <jats:italic>fibulin\u20102<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice and WT mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 132 patients were enrolled in this study. The fibulin\u20102 level in the bone trauma group was lower than that in the recovered bone trauma group (3.39\u2009\u00b1\u20091.41 vs. 4.30\u2009\u00b1\u20091.38\u2009ng\/mL, <jats:italic>t<\/jats:italic>\u2009=\u20092.948, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and also lower than that in the volunteers without bone trauma group (3.39\u2009\u00b1\u20091.41 vs. 4.73\u2009\u00b1\u20091.67\u2009ng\/mL, <jats:italic>t<\/jats:italic>\u2009=\u20094.135, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). <jats:italic>Fibulin\u20102<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice are more prone to infection. Compared with those in WT mice, spleen function and thymus function in <jats:italic>fibulin\u20102<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice were impaired. Immunohistochemical staining revealed that compared with those in WT mice, significantly fewer CD4+ T cells, CD8+ T cells, and CD19+ B cells were noted in the spleen and thymus of <jats:italic>fibulin\u20102<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The plasma fibulin\u20102 level was lower in patients with bone trauma. Decreased fibulin\u20102 is associated with immune dysfunction after bone trauma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.846","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T12:06:37Z","timestamp":1683288397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fibulin\u20102: A potential regulator of immune dysfunction after bone trauma"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-1466","authenticated-orcid":false,"given":"Shidan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Affiliated Hospital of 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jijie","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-6125","authenticated-orcid":false,"given":"Qiaohui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cancer Center, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Military Traffic Injury Prevention, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Medicine, State Key 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