{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:12:29Z","timestamp":1789593149794,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860033"],"award-info":[{"award-number":["81860033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160034"],"award-info":[{"award-number":["82160034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Galectin\u20109 and myeloid\u2010derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been fully elucidated. This study aimed to analyze the prognosis values of Galectin\u20109 and MDSCs in CLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The concentrations of Galectin\u20109, argininase\u20101, and inducible nitric oxide synthase in serum were detected by enzyme\u2010linked immune sorbent assay. The expression of Tim\u20103 protein in peripheral blood mononuclear cell was detected by Western blot. Flow cytometry was used to analyze the percentages of Tim\u20103 on T\u2010cells (CD3<jats:sup>+<\/jats:sup>T, CD4<jats:sup>+<\/jats:sup>T, and CD8<jats:sup>+<\/jats:sup>T cells) and MDSCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that Galectin\u20109 and MDSCs significantly increased in CLL patients and were closely related to the disease progression. Patient's receiver operating characteristic, progression\u2010free survival, and Cox regression analysis showed that Galectin9 and MDSCs were poor prognostic factors of CLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Galectin\u20109 and MDSCs were associated with clinical progression and could be important prognostic indicators for CLL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.853","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T13:26:44Z","timestamp":1683552404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Galectin\u20109 and myeloid\u2010derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-9442","authenticated-orcid":false,"given":"Xierenguli","family":"Alimu","sequence":"first","affiliation":[{"name":"Center of 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