{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:35Z","timestamp":1753869275220,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the maternal and umbilical cord blood antibody levels, after COVID vaccination during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The women who received the COVID\u201019 vaccine (Sinopharm) during pregnancy were included. Maternal and cord blood samples were tested to detect the severe acute respiratory syndrome coronavirus 2 receptor binding domain (RBD) specific antibodies. In addition, obstetric information and side effects after vaccination were gathered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 23 women were included. Eleven pregnant women took two doses and 12 cases received a single dose of the vaccine. No IgM antibody was detected in any maternal blood or cord blood samples. The RBD\u2010specific Immunoglobulin G (IgG) antibody was positive in mothers receiving 2 doses of the vaccine and their infants. But the antibody titers were under the positive cut\u2010off threshold for the other 12 women who were vaccinated with a single dose. Women who received both doses of vaccine had significantly higher IgG levels than a single dose of Sinopharm (<jats:italic>p<\/jats:italic>\u2009=\u2009.025). The same result was demonstrated in infants born to these mothers (<jats:italic>p<\/jats:italic>\u2009=\u2009.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a significant correlation between maternal and neonatal IgG concentrations. Although, receiving both doses of the BBIBP\u2010CorV vaccine (not 1 dose) during pregnancy is highly beneficial for increasing humoral immunity for the mother and fetus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.874","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T13:00:00Z","timestamp":1686747600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cord blood antibodies following BBIBP\u2010CorV (Sinopharm) vaccination during pregnancy"],"prefix":"10.1002","volume":"11","author":[{"given":"Sedigheh","family":"Hantoushzadeh","sequence":"first","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim","family":"Eshraghi","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarang","family":"Younesi","sequence":"additional","affiliation":[{"name":"Nilou Laboratory Prenatal Screening Department Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammadreza","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Center for Immunodeficiencies, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Mehdi","family":"Hasheminejad","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pegah","family":"Rashidian","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeedeh","family":"Shirdel","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Asadi","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-7112","authenticated-orcid":false,"given":"Marjan","family":"Ghaemi","sequence":"additional","affiliation":[{"name":"Vali\u2010E\u2010Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.054"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/idr13030064"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.06.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1658"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.05.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004438"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab266"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.03.023"},{"key":"e_1_2_8_11_1","unstructured":"Metro ManilaP.Emergency Use Authorization (EUA) for COVID\u201019 Vaccine (Vero Cell) Inactivated manufactured by Sinopharm\/China National Pharmaceutical Group\/Wuhan Institute of Biological Products Co. Ltd: FOOD AND DRUG ADMINISTRATION. 2021.https:\/\/www.google.com\/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwim3uaChf_5AhWphf0HHXUvCFoQFnoECAgQAQ&url=https%3A%2F%2Fwww.fda.gov.ph%2Fwp-content%2Fuploads%2F2021%2F08%2FEUA-Sinopharm-2-World-Traders-Website.pdf&usg=AOvVaw1gF0DqleyWh928PXNRuRKH"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.04.030"},{"key":"e_1_2_8_13_1","unstructured":"Ministry of Health and Medical Education. Iran's Health Ministry.\u00a02022.https:\/\/irangov.ir\/ministry-of-health-and-medical-education"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0000607"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095026882000196X"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00703-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01499"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31169-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150319"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004693"},{"key":"e_1_2_8_21_1","article-title":"Effectiveness of maternal vaccination with mRNA COVID\u201019 vaccine during pregnancy against COVID\u201019\u2013associated hospitalization in infants aged","volume":"71","author":"Halasa N","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_22_1","article-title":"COVID\u201019 vaccine response in pregnant and lactating women: a cohort study","author":"Gray KJ","year":"2021","journal-title":"medRxiv"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100492"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.735394"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6944e3"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11164720"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.10.003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14014"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9060675"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.5683"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109072"}],"container-title":["Immunity, Inflammation and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iid3.874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:07:33Z","timestamp":1748002053000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iid3.874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/iid3.874"],"URL":"https:\/\/doi.org\/10.1002\/iid3.874","archive":["Portico"],"relation":{},"ISSN":["2050-4527","2050-4527"],"issn-type":[{"type":"print","value":"2050-4527"},{"type":"electronic","value":"2050-4527"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"2022-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e874"}}