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PACSs involve many organs, including the nervous, gustatory, and immune systems. One of the PACSs after SARS\u2010CoV\u20102 infection and vaccination is Guillain\u2010Barr\u00e9 syndrome (GBS). The incidence rate of GBS after SARS\u2010CoV\u20102 infection or vaccination is low. However, the high prevalence of COVID\u201019 and severe complications of GBS, for example, autonomic dysfunction and respiratory failure, highlight the importance of post\u2010COVID\u201019 GBS. It is while patients with simultaneous COVID\u201019 and GBS seem to have higher admission rates to the intensive care unit, and demyelination is more aggressive in post\u2010COVID\u201019 GBS patients. SARS\u2010CoV\u20102 can trigger GBS via several pathways like direct neurotropism and neurovirulence, microvascular dysfunction and oxidative stress, immune system disruption, molecular mimicry, and autoantibody production. Although there are few molecular studies on the molecular and cellular mechanisms of GBS occurrence after SARS\u2010CoV\u20102 infection and vaccination, we aimed to discuss the possible pathomechanism of post\u2010COVID\u201019 GBS by gathering the most recent molecular evidence.<\/jats:p>","DOI":"10.1002\/iid3.875","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:37:31Z","timestamp":1684237051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["COVID\u201019 as a trigger of Guillain\u2010Barr\u00e9 syndrome: A review of the molecular mechanism"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-0002","authenticated-orcid":false,"given":"Mahdi","family":"Malekpour","sequence":"first","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Khanmohammadi","sequence":"additional","affiliation":[{"name":"Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran"},{"name":"Research Center for Immunodeficiencies, Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Javad Entezari","family":"Meybodi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorsa","family":"Shekouh","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Rahmanian","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Kardeh","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1518-1583","authenticated-orcid":false,"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000044"},{"key":"e_1_2_8_3_1","volume-title":". 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