{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:44:29Z","timestamp":1787039069011,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Modern pharmacological studies show that Epimedium sagittatum Maxim (EPI) has antioxidant, antiapoptotic, anti\u2010inflammatory effects. However, the effects of EPI on adriamycin\u2010induced nephropathy are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The main purpose of this study is to investigate the effects of EPI on adriamycin\u2010induced nephropathy in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The chemical composition of EPI was detected by high performance liquid chromatography. Network pharmacology was used to collect the effects of EPI on adriamycin nephropathy; renal histological changes, podocyte injury, inflammatory factors, oxidative stress levels, apoptosis levels, and the PI3K\/AKT signaling pathway were examined. Moreover, analyze the effects of icariin (the representative component of EPI) on adriamycin\u2010induced apoptosis and PI3K\/AKT signaling pathway of NRK\u201052e cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Network pharmacological results suggested that EPI may ameliorate adriamycin\u2010induced nephropathy by inhibiting inflammatory response and regulating the PI3K\/AKT signaling pathway. The experimental results showed that EPI could improve pathological injury, renal function, podocyte injury, and inhibit inflammation, oxidative stress, apoptosis in adriamycin\u2010induced nephropathy rats through the PI3K\/AKT signaling pathway. Furthermore, icariin inhibited adriamycin\u2010induced mitochondrial apoptosis in NRK\u201052e cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggested that EPI ameliorates adriamycin\u2010induced nephropathy by reducing inflammation and apoptosis through the PI3K\/AKT signaling pathway, icariin may be the pharmacodynamic substance basis for this effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.904","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T13:18:42Z","timestamp":1686748722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Epimedium sagittatum Maxim ameliorates adriamycin\u2010induced nephropathy by restraining inflammation and apoptosis via the PI3K\/AKT signaling pathway"],"prefix":"10.1002","volume":"11","author":[{"given":"Ru","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbo","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3671-231X","authenticated-orcid":false,"given":"Xiaoke","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Henan University of Chinese Medicine Zhengzhou China"},{"name":"The Engineering and Technology Center for Chinese Medicine Development of Henan Province Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211006171"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14822"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2741\/4818"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521220"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"168","article-title":"Potential roles of Kleinhovia hospita L. 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