{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:16:37Z","timestamp":1762377397595,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The global spread of coronavirus disease 2019 (COVID\u201019) has resulted in a significant disease burden, yet asthma patients do not have the expected high morbidity and mortality rates in the pandemics of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To find the difference of angiotensin\u2010converting enzyme 2 (ACE2) in asthma and nonasthma children and evaluate the effect of inhaled corticosteroids (ICS) on its expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ACE2, immunoglobulin E (IgE), and eosinophils were tested in different children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 157 children aged 3\u201316 years were enrolled. The expression of ACE2 in asthma children were lower than nonasthma children (<jats:italic>T<\/jats:italic>\u2009=\u2009\u22122.512, <jats:italic>p<\/jats:italic>\u2009=\u2009.013). Allergic nonasthma children had a significant higher ACE2 expression than children with allergic asthma (<jats:italic>p<\/jats:italic>\u2009=\u2009.013) and nonallergic asthma (<jats:italic>p<\/jats:italic>\u2009=\u2009.029). The expression of ACE2 had no significant difference between first\u2010diagnosed asthma children and that had been treated with ICS for \u22656 months (<jats:italic>F<\/jats:italic>\u2009=\u20090.028, <jats:italic>p<\/jats:italic>\u2009=\u2009.598). The allergic asthma children showed a significantly higher eosinophils cells (EC) count than the allergic nonasthma (<jats:italic>W<\/jats:italic>\u2009=\u2009200, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and nonallergic nonasthma children (<jats:italic>W<\/jats:italic>\u2009=\u20091089, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Nonallergic asthma children also had a significant higher EC count than the allergic non\u2010asthma (<jats:italic>W<\/jats:italic>\u2009=\u2009182.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and nonallergic non\u2010asthma (<jats:italic>W<\/jats:italic>\u2009=\u2009200.5, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) children. There was no significant difference in IgE levels between asthmatic children and non\u2010asthmatic children (<jats:italic>W<\/jats:italic>\u2009=\u20092792.5, <jats:italic>p<\/jats:italic>\u2009=\u2009.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating ACE2 levels in asthmatic children were lower than those in non\u2010asthmatic children and ICS treatment for \u22656 months did not affect the expression of ACE2 in peripheral blood in the asthma children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.922","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T09:29:47Z","timestamp":1690450187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression of circulating angiotensin\u2010converting enzyme 2 in children with asthma and the effects of inhaled 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