{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:22:00Z","timestamp":1769066520909,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the distribution of bacterial pathogens of lower respiratory tract infection (LRTI) in hospitalized elderly patients during the COVID\u201019 epidemic and to explore the influence of COVID\u201019 on the distribution of bacterial pathogens, to provide guidance for clinical diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Specimens of sputum from elderly LRTIs patients at Fuding Hospital of China were consecutively collected from October 2022 to January 2023. Cultures and identification were done, and RT\u2010PCR was employed to detect SARS\u2010Cov\u20102 nucleic acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 195 isolates were characterized in 163 sputum samples of consecutive hospitalized elderly patients, of which 11.3% were Gram\u2010positive bacteria and 88.7% were Gram\u2010negative. The top of frequently isolated pathogens was <jats:italic>Klebsiella pneumonia<\/jats:italic> (30.3%), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (19.0%), <jats:italic>Acinetobacter baumannii<\/jats:italic> (12.8%), <jats:italic>Stenotrophomonas maltophili<\/jats:italic>, (7.7%), <jats:italic>Escherichia coli<\/jats:italic> (7.2%). According to the results of novel coronavirus nucleic acid detection, the 163 patients were divided into COVID\u201019 group and non\u2010COVID control (CNT) group. The comparison of bacterial distribution between the groups revealed that <jats:italic>Stenotrophomonas maltophilia<\/jats:italic> was lower in the COVID\u201019 than in the CNT group, while <jats:italic>A. baumannii<\/jats:italic> was higher in the COVID\u201019 group, and the difference was statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The major bacteria identified in sputum culture of hospitalized elderly patients were <jats:italic>K. pneumonia<\/jats:italic>, <jats:italic>P. aeruginosa<\/jats:italic>, <jats:italic>A. baumannii<\/jats:italic>, <jats:italic>S. maltophilia<\/jats:italic>, and <jats:italic>E. coli<\/jats:italic>. Furthermore, the distribution of <jats:italic>S. maltophilia<\/jats:italic> and <jats:italic>A. baumannii<\/jats:italic> between the COVID\u201019 and CNT groups was found to be significantly different (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), while there were no significant differences in the distribution of other bacteria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.931","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T04:31:47Z","timestamp":1689136307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of COVID\u201019 on the distribution of pathogenic bacteria in the lower respiratory tract of the elderly"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4305-8213","authenticated-orcid":false,"given":"Shi\u2010Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Fuding Hospital Fujian University of Traditional Chinese Medicine Fuding Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Fuding Hospital Fujian University of Traditional Chinese Medicine Fuding Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Fuding Hospital Fujian University of Traditional Chinese Medicine Fuding Fujian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Fuding Hospital Fujian University of Traditional Chinese Medicine Fuding Fujian 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