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Chronic inflammatory or autoimmune diseases are associated with many diseases in humans, including asthma, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease and cancer. Splenic tyrosine kinase (SYK) is a non\u2013receptor tyrosine kinase that plays an important role in immune receptor signalling in immune and inflammatory responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a review article in which we searched for keywords \u201csplenic tyrosine kinase\u201d, \u201cinflammation\u201d and \u201cautoimmune diseases\u201d in published literature such as Pubmed and Web of Science to collect relevant information and then conducted a study focusing on the latest findings on the involvement of SYK in chronic inflammatory or autoimmune diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This paper reviews the regulation of Fc\u03b3, NF\u2013\u03baB, B cell and T cell\u2013related signalling pathways by SYK, which contributes to disease progression in chronic inflammatory and autoimmune diseases such as airway fibrosis, inflammatory skin disease and inflammatory bowel disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This paper shows that SYK plays an important role in chronic inflammatory and autoimmune diseases. syk targets hematological, autoimmune and other inflammatory diseases and therefore, inhibition of SYK expression or blocking its related pathways may provide new ideas for clinical prevention and treatment of inflammatory or autoimmune diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.934","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T09:22:05Z","timestamp":1690449725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases"],"prefix":"10.1002","volume":"11","author":[{"given":"Yaqi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine Jining Medical University 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