{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:21:31Z","timestamp":1754162491365,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vaccination is an important method for the prevention of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) transmission. There is currently a lack of real\u2010world clinical data regarding the safety and efficacy of coronavirus disease 2019 (COVID\u201019) vaccines with respect to plaque psoriasis treatment involving tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u201017A (IL\u201017A) inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We longitudinally analyzed 152 patients with plaque psoriasis, 86 of whom received two doses of inactivated COVID\u201019 vaccine (either BBIBP\u2010CorV or CoronaVac). Comparisons were made between patients undergoing treatment with biologics (TNF\u2010 \u03b1 inhibitors or IL\u201017A inhibitors) or acitretin. Routine blood tests were used to assess safety; the psoriasis area and severity index (PASI) and dermatology life quality index (DLQI) were used to assess efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After inactivated COVID\u201019 vaccination, biologics retained considerable advantages in terms of improving skin lesions (measured by PASI) and quality of life (measured by DLQI), compared with conventional treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 and <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01, respectively). Routine blood tests and hepatorenal function analyses suggested that inactivated SARS\u2010CoV\u20102 vaccines did not alter the safety of biologics treatment (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inactivated SARS\u2010CoV\u20102 vaccines do not have significant impacts on the safety and efficacy of biologics (TNF\u2010\u03b1 inhibitors or IL\u201017A inhibitors) in patients with moderate to severe plaque psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.938","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T09:30:04Z","timestamp":1690450204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A study of the efficacy and safety of plaque psoriasis treatment by TNF\u2010\u03b1 and IL\u201017A inhibitor biologics in patients who received the inactivated SARS\u2010CoV\u20102 vaccine"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-0059","authenticated-orcid":false,"given":"Shuhong","family":"Ye","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'An Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'An Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zining","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'An Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'An Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University Medical School in Department of Nursing  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'An Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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