{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:45:45Z","timestamp":1787510745217,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>BK polyomavirus (BKPyV)\u2010associated nephropathy (BKPyVAN) can cause a significant risk of allograft impairment after kidney transplantation (KT). Intact BKPyV\u2010specific immunity is associated with viral containment. This study investigated BKPyV\u2010specific immunological factors among KT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective study in a single transplant center from January 2019 to August 2019 assessed associations between clinical and immunological characteristics, with a focus on BKPyV\u2010cell\u2010specific immunity and BKPyVAN, among KT recipients aged \u226515 years. The numbers of interferon\u2010gamma (IFN\u2010\u03b3)\u2010producing CD4\n                      <jats:sup>+<\/jats:sup>\n                      \u00a0T, CD8\n                      <jats:sup>+<\/jats:sup>\n                      \u00a0T, natural killer (NK), and natural killer\u00a0T (NKT) cells were measured after stimulation with large T antigen and viral capsid protein 1 (VP1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 100 KT recipients were included (mean age\u2009\u00b1\u2009SD, 42\u2009\u00b1\u200911 years); 35% of the recipients were female patients, and 70% had received induction immunosuppressive therapy. The 1\u2010year cumulative incidence of high\u2010level BKPyV DNAuria (possible BKPyVAN) and (presumptive BKPyVAN) was 18%. Among 40 patients with immunological factor data, pre\u2010KT %NK cells (hazard ratio [HR], 1.258; 95% confidence interval [CI], 1.077\u20131.469;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004) and %VP1\u2010specific NK cells (HR, 1.209; 95% CI, 1.055\u20131.386;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.006) were factors independently associated with possible and presumptive BKPyVAN. KT recipients with possible and presumptive BKPyVAN were more likely to exhibit significant mean coefficients of %NK, %VP1\u2010specific NK, and %NKT cells at 1 month after KT than before KT (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with nonspecific and VP1\u2010specific NK cells before KT and increasing numbers of these cells after KT may be at risk for high\u2010level BKPyV DNAuria and presumptive BKPyVAN. Further studies are needed to determine the utility of BKPyV\u2010specific innate immune surveillance in predicting the occurrence of BKPyVAN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/iid3.956","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:58:18Z","timestamp":1693209498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and immunological characteristics for BK polyomavirus\u2010associated nephropathy after kidney transplantation"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-8034","authenticated-orcid":false,"given":"Tanaya","family":"Siripoon","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine 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