{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:42Z","timestamp":1753869282058,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunity Inflam &amp;amp; Disease"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>: Rowell syndrome (RS) is an uncommon condition characterized by erythema multiforme (EM)\u2010like lesions and lupus erythematosus. It is more common in females, and EM may be the first manifestation of the disease with positive autoantibodies, such as antinuclear antibody (ANA), SSA, SSB and rheumatoid factor. The pathogenesis of RS is unknown and is likely caused by drug induction, ultraviolet exposure and infection. <jats:bold>Method<\/jats:bold>: We describe a case of RS from China which presented as characteristic targetoid\u2010like lesions and chilblain\u2010like erythema on hands and feet. This is a case of RS in a female patient from the inpatient department of dermatology. <jats:bold>Results<\/jats:bold>: A 41\u2010year\u2010old female with systemic lupus erythematosus\u00a0exhibited chilblain\u2010like erythema and characteristic EM lesions on her extremities. She tested positive for serum ANA\u00a0(1:320) and anti\u2010double\u2010stranded DNA, as well as other autoantibodies. Systemic glucocorticoids and hydroxychloroquine worked effectively for her. <jats:bold>Conclusion<\/jats:bold>: The present case met diagnostic criteria of RS. Notably, there was a co\u2011occurrence of facial butterfly erythema, chilblain\u2010like erythema and EM lesions distributed on the limbs in this case.<\/jats:p>","DOI":"10.1002\/iid3.979","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:53:10Z","timestamp":1693223590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targetoid\u2010like lesions and chilblain\u2010like erythema manifested on hands and feet: A case of Rowell syndrome from China"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-7676","authenticated-orcid":false,"given":"Yanqiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanpeng","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangxing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China Chengdu 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