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It acts by specifically binding to the constant domain (C\u03f53) of free human IgE in the blood and interstitial fluid. Although efficacious, use of omalizumab is limited due to restrictions on patient weight and pre\u2010existing IgE levels, and frequent dosing (q2\u20134 weeks). A vaccine inducing anti\u2010IgE antibodies has the potential for similar clinical benefits with less frequent dosing and relatively lower cost of goods. We developed a vaccine containing two IgE peptide\u2010conjugates targeting the C\u03f53 domain of human IgE. As part of preclinical evaluation of the vaccine to optimize formulation and dose prior to initiating clinical studies, we evaluated the vaccine in non\u2010human primates, and demonstrate the induction of anti\u2010peptide antibodies that can bind to conformationally intact human IgE and are capable, at least in some animals, of substantial lowering circulating IgE levels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iid3.98","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T19:05:28Z","timestamp":1459623928000},"page":"135-147","source":"Crossref","is-referenced-by-count":12,"title":["Immunogenicity of a peptide\u2010based anti\u2010IgE conjugate vaccine in non\u2010human primates"],"prefix":"10.1002","volume":"4","author":[{"given":"Risini D.","family":"Weeratna","sequence":"first","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics Ottawa Laboratories Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghania","family":"Chikh","sequence":"additional","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics Ottawa Laboratories Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics Ottawa Laboratories Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Thorn","sequence":"additional","affiliation":[{"name":"Pfizer Biotherapeutics Pharmaceutical Sciences St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Merson","sequence":"additional","affiliation":[{"name":"Pfizer Biotherapeutics Pharmaceutical Sciences St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"McCluskie","sequence":"additional","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics Ottawa Laboratories Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Champion","sequence":"additional","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Pfizer Vaccine Immunotherapeutics Ottawa Laboratories Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.2007. 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