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In addition, Covid\u201019 may enhance the propagation of acute pulmonary histoplasmosis due to lung injury and inflammation, and using corticosteroids in severely affected Covid\u201019 patients may reactivate latent pulmonary histoplasmosis. Likewise, activation of inflammatory signaling pathways during <jats:italic>H. capsulatum<\/jats:italic> infection may increase the severity of Covid\u201019 and vice versa. Furthermore, lymphopenia in Covid\u201019 may increase the risk for the progress of pulmonary histoplasmosis besides activation of inflammatory signaling pathways during <jats:italic>H. capsulatum<\/jats:italic> infection may increase the severity of Covid\u201019 and vice versa. Therefore, this critical review aimed to find the potential link between Covid\u201019 pneumonia and pulmonary histoplasmosis concerning the immunological response.<\/jats:p>","DOI":"10.1002\/iid3.989","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:29:36Z","timestamp":1695979776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Insights on Covid\u201019 with superimposed pulmonary histoplasmosis: The possible nexus"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-6139","authenticated-orcid":false,"given":"Yahya A.","family":"Almutawif","sequence":"first","affiliation":[{"name":"Department of Medical Laboratories Technology, College of Applied Medical Sciences Taibah University  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayder M.","family":"Al\u2010kuraishy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Medicine, College of Medicine Al\u2010Mustansiriyia University  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali I.","family":"Al\u2010Gareeb","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Medicine, College of Medicine Al\u2010Mustansiriyia University  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[{"name":"Department of Science and Engineering Novel Global Community Educational Foundation  Hebersham New South Wales Australia"},{"name":"AFNP Med  Wien Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Department of Surgery II, University Hospital Witten\u2010Herdecke, Heusnerstrasse 40 University of Witten\u2010Herdecke  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-5409","authenticated-orcid":false,"given":"Hamza M. 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