{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:13:26Z","timestamp":1782267206290,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,11,6]],"date-time":"2001-11-06T00:00:00Z","timestamp":1005004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kaposi's sarcoma\u2010associated herpesvirus (KSHV) is a gammaherpesvirus etiologically linked to primary effusion lymphoma (PEL), to a subset of multicentric Castleman's disease and to Kaposi's sarcoma (KS), the most common neoplasm associated with AIDS. Among KSHV\u2010infected individuals, the risk of KS is much higher in those with human immunodeficiency\u20101 (HIV\u20101) infection than among those with other types of immunosuppression, suggesting a direct action of HIV\u20101 on KSHV replication. We show in our report that BC\u20103 cells, a chronically KSHV\u2010infected B\u2010cell line of a PEL origin, are permissive to HIV\u20101, offering a new tool for studying the interactions between these 2 viruses. In these cells, HIV\u20101 infection leads to reactivation of latent KSHV genomes, as demonstrated by the expression of KSHV lytic viral mRNAs. Although recombinant HIV\u20101 gp120 fails to enhance herpesvirus expression<jats:italic>,<\/jats:italic> transient transfection of the HIV\u20101 trans\u2010activator Tat suffices to reactivate latent KSHV<jats:italic>.<\/jats:italic> By showing that HIV\u20101 infection directly reactivates latent KSHV, our results suggest a direct role of HIV\u20101 in the onset of KS in coinfected individuals. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10086","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"791-795","source":"Crossref","is-referenced-by-count":45,"title":["HIV\u20101 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma\u2010associated herpesvirus (KSHV) reactivation"],"prefix":"10.1002","volume":"97","author":[{"given":"Rastine","family":"Merat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Lebbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"de 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