{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:49:48Z","timestamp":1763966988394,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,12,13]],"date-time":"2001-12-13T00:00:00Z","timestamp":1008201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"crossref","award":["87ER60548"],"award-info":[{"award-number":["87ER60548"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["CA57569"],"award-info":[{"award-number":["CA57569"]}]},{"name":"Eric Lightner Memorial Fund"},{"name":"Ataxia-Telangiectasia Medical Research Foundation"},{"name":"Ministerio de Educacion y Cultura","award":["EX96-0035093175"],"award-info":[{"award-number":["EX96-0035093175"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We analyzed the role of 4 genes, <jats:italic>TCL\u20101<\/jats:italic>, <jats:italic>MTCP\u20101<\/jats:italic>, <jats:italic>TML\u20101<\/jats:italic> and <jats:italic>ATM<\/jats:italic>, in the early pathogenesis of T cell leukemia, with particular interest in the characteristics of long\u2010standing non\u2010leukemic clonal proliferations in ataxia\u2010telangiectasia (A\u2010T) patients. Five patients were studied: 4 patients had A\u2010T (2 of whom had non\u2010leukemic clonal proliferations [ATCP]), 1 had B cell lymphoma and 1 had T\u2010ALL; a fifth patient with T\u2010PLL did not have A\u2010T. We measured the levels of expression for <jats:italic>TCL\u20101<\/jats:italic>, <jats:italic>MTCP\u20101<\/jats:italic> and <jats:italic>TML\u20101<\/jats:italic>. <jats:italic>TCL\u20101<\/jats:italic>, not expressed in unstimulated mature T cells, was upregulated in the peripheral blood leukocytes (PBL) of the 2 A\u2010T patients with ATCP. It was also expressed in the malignant cells of the A\u2010T patient with B cell lymphoma and the T\u2010PLL cells of the patient without A\u2010T. In the same cells, <jats:italic>MTCP\u20101<\/jats:italic> type A was expressed equally in all 5 patients, as well as in the controls; <jats:italic>MTCP\u20101<\/jats:italic> type B transcripts were not observed. <jats:italic>TML\u20101<\/jats:italic>, also not expressed in unstimulated T cells, was expressed in the PBL of one A\u2010T patient with ATCP and in the leukemic cells of the non\u2010A\u2010T T\u2010PLL patient. These expression patterns were compared to cellular immunophenotypes. The non\u2010leukemic clonal T cell populations had the characteristics of immature T cells. We conclude that <jats:italic>TCL\u20101<\/jats:italic> and <jats:italic>TML\u20101<\/jats:italic> play a role in cell proliferation and survival but are not pivotal genes in the progression to malignancy, even when the <jats:italic>ATM<\/jats:italic> gene is mutated. Additional genetic alterations must occur to initiate tumorigenesis. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10102","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"726-731","source":"Crossref","is-referenced-by-count":16,"title":["<i>TCL\u20101<\/i>, <i>MTCP\u20101<\/i> and <i>TML\u20101<\/i> gene expression profile in non\u2010leukemic clonal proliferations associated with ataxia\u2010telangiectasia"],"prefix":"10.1002","volume":"97","author":[{"given":"Helen H.","family":"Chun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Castellv\u00ed\u2010Bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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