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In this study, we evaluate the association among genetic alterations of Ki\u2010<jats:italic>ras<\/jats:italic> and <jats:italic>p53<\/jats:italic>, microsatellite instability and having a family history of colorectal cancer in a study of incident colon cancer cases (<jats:italic>n<\/jats:italic> = 1993) and population\u2010based controls (<jats:italic>n<\/jats:italic> = 2,410). Although there was a slight nonsignificant increase in risk of having an unstable tumor among those with a family history of colorectal cancer, this increase in risk disappeared after excluding those people with a known mutation in either of the mismatch repair genes <jats:italic>hMLH1<\/jats:italic> or <jats:italic>hMSH2<\/jats:italic>. A family history of colorectal cancer was not associated with Ki\u2010<jats:italic>ras<\/jats:italic> mutations overall, although those with a G to T mutation of the second base of codon 12 were more likely to have a family history of colorectal cancer than were those without this specific type of Ki\u2010<jats:italic>ras<\/jats:italic> mutation. Cases with <jats:italic>p53<\/jats:italic> mutations were less likely to have a family history of colorectal cancer than were cases without a <jats:italic>p53<\/jats:italic> mutation. We believe that, given the general lack of association between having a family history of colorectal cancer and genetic alterations in tumors, these alterations are acquired through disease pathways that involve exposure from diet, lifestyle or other environmental factors. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10148","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"823-827","source":"Crossref","is-referenced-by-count":19,"title":["Associations between family history of colorectal cancer and genetic alterations in tumors"],"prefix":"10.1002","volume":"97","author":[{"given":"Martha 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