{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:51:24Z","timestamp":1786963884684,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,18]],"date-time":"2001-12-18T00:00:00Z","timestamp":1008633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria","award":["FIS 98\/0646"],"award-info":[{"award-number":["FIS 98\/0646"]}]},{"name":"National Cancer Institute, National Institutes of Health","award":["NO1-CO-56000"],"award-info":[{"award-number":["NO1-CO-56000"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transmission routes of Kaposi's sarcoma\u2010associated herpesvirus (KSHV) in the general population are poorly understood. Whereas sexual transmission appears to be common in homosexual men, the evidence for heterosexual transmission is less convincing. In our study, prevalence of KSHV infection was examined among women in the Spanish general population and among sex workers. Subjects consisted of 100 prostitutes and 100 women randomly sampled from the general population and age\u2010matched to the prostitutes. Women had a personal interview and gynecologic examinations in which a blood sample, cervical cells and oral cells were obtained. Peripheral blood mononuclear cells (PBMC), oral and cervical samples were tested for KSHV DNA by quantitative real\u2010time PCR. Sera were tested for antibodies against human immunodeficiency virus (HIV) by ELISA and against KSHV by latent IFA and K8.1 ELISA. Women who were positive in either serologic assay or PCR were considered infected by KSHV. Human papillomavirus (HPV) DNA in cervical scrapes were evaluated using the Hybrid Capture System\u2122. The study population had an average age of 30 years and were HIV\u2010negative. Women from the general population were largely of Spanish nationality, and 61% reported lifetime monogamy. The majority of the prostitutes (76%) were immigrants, primarily from South America. Sex workers were twice as likely to be infected with KSHV than women in the general population (16% <jats:italic>vs.<\/jats:italic> 8%, prevalence odds ratio [OR] = 2.2). KSHV was more prevalent among HPV DNA\u2010positive women (OR = 2.5) and among women with an early age at first sexual intercourse (OR = 2.7, <jats:italic>p<\/jats:italic> &lt; 0.05). KSHV DNA was detected by PCR in 3% of the oral cavity samples, in 2% of the cervical samples of the prostitutes and in 1% of the cervical samples of women in the general population. All PBMC samples were negative. These results suggest that in low\u2010risk countries for KSHV, oral shedding and heterosexual contacts are potential pathways for KSHV transmission. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10190","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"155-158","source":"Crossref","is-referenced-by-count":84,"title":["Prevalence of Kaposi's sarcoma\u2010associated herpesvirus infection in sex workers and women from the general population in Spain"],"prefix":"10.1002","volume":"98","author":[{"given":"S\u00edlvia","family":"de Sanjos\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Sol\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilio","family":"Palacio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Almirall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Goedert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Xavier","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Whitby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91619-9"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505043321802"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199809000-00007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03240-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/315456"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.5.465"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<817::AID-IJC2>3.0.CO;2-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.0983"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804023381403"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/315039"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/314926"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-918"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07560-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199906173402403"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610173351614"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1128\/JVI.72.7.6223-6227.1998","article-title":"Human herpesvirus 8 in the prostate glands of men with Kaposi's sarcoma","volume":"72","author":"Diamond C","year":"1998","journal-title":"J Virol"},{"key":"e_1_2_6_19_2","first-page":"674","article-title":"Enhanced detection of human herpesvirus\u20108 and cytomegalovirus in semen of HIV\u2010seropositive asymptomatic heterosexual men living in Central Africa","volume":"12","author":"Belec L","year":"1998","journal-title":"Aids"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199702000-00001"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011093431904"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199705000-00008"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.4.1150-1153.1999"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/514045"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/315426"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.9.7083-7087.1997"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/314765"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1086\/314563"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-200004010-00011"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(00)00244-5"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1086\/515649"},{"key":"e_1_2_6_32_2","volume-title":"Sistema integrat de vigilanca epidemiogica del l'HIV\/Sida a Catalunya (SIVES): informe annual 1999","author":"CEESCAT (C.d.E.E.s.l.S.d.C.)","year":"2000"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10190","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:01:01Z","timestamp":1697536861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["10.1002\/ijc.10190"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10190","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,18]]}}}