{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:22:26Z","timestamp":1790968946013,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,5,23]],"date-time":"2001-05-23T00:00:00Z","timestamp":990576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2001,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A woman with a family history of brain tumors in her daughter and sister presented with a breast cancer. She subsequently developed two metachronous primary tumors: a small\u2010cell lung cancer and a colon carcinoma. These tumors arose within the internal mammary radiotherapy field and within the field irradiated for ovariolysis. The p53 gene was analyzed in whole blood lymphocytes using a functional assay developed in yeast<jats:italic>Saccharomyces cerevisiae,<\/jats:italic>which tests the transcriptional competence of p53. DNA from the colon cancer cells was analyzed by polymerase chain reaction and sequencing. The patient had a germline\u2010inactivating p53 mutation, confirming the diagnosis of Li\u2010Fraumeni syndrome (LFS). The colon tumor and the lung tumor both conserved the mutant p53 allele but had lost the wild\u2010type allele. This observation and the experimental data suggest an abnormal sensitivity of LFS patients to radiogenic carcinogenesis. The indications and extent of radiotherapy in patients with a clinical or molecular diagnosis of LFS should be discussed individually and should take into account the risk of secondary neoplasms arising in the radiation fields. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.1021","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:49:13Z","timestamp":1030312153000},"page":"238-242","source":"Crossref","is-referenced-by-count":130,"title":["Two metachronous tumors in the radiotherapy fields of a patient with Li\u2010Fraumeni syndrome"],"prefix":"10.1002","volume":"96","author":[{"given":"Jean\u2010Marc","family":"Limacher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Frebourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanti","family":"Natarajan\u2010Ame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Bergerat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,7,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-71-4-747"},{"key":"e_1_2_5_3_2","first-page":"5358","article-title":"A cancer family syndrome in twenty\u2010four kindreds","volume":"48","author":"Li FP","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_5_4_2","first-page":"6094","article-title":"Follow up study of twenty\u2010four families with Li\u2010Fraumeni syndrome","volume":"51","author":"Garber JE","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.328"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.8.606"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1978757"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/348747a0"},{"key":"e_1_2_5_9_2","first-page":"3245","article-title":"Germline mutations of TP53 in Li\u2010Fraumeni families: an extended study of 39 families","volume":"57","author":"Varley JM","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2528"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198721000-00017"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.2.262"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92517-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3963"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/oso\/9780199636570.003.0013","volume-title":"Mutation detection: a practical approach","author":"Frebourg T","year":"1998"},{"key":"e_1_2_5_16_2","first-page":"1","article-title":"Secondary cancers after radiotherapy: an introduction","volume":"32","author":"Cosset JM","year":"1997","journal-title":"Radioprotection"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.2307\/3577030"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197412)34:6<2056::AID-CNCR2820340626>3.0.CO;2-Z"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/358015a0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/095530097143202"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/095530096145139"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2307\/3578616"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1200838"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.4.691"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.9.3982"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-225"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0994-66"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(93)90001-V"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.1021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.1021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T20:44:35Z","timestamp":1703882675000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.1021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,19]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,8,20]]}},"alternative-id":["10.1002\/ijc.1021"],"URL":"https:\/\/doi.org\/10.1002\/ijc.1021","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,19]]}}}