{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:52:19Z","timestamp":1791100339256,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,3,8]],"date-time":"2002-03-08T00:00:00Z","timestamp":1015545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To explore a possible influence of the immune system in the development of brain tumors, we evaluated the relationship between history of allergies and autoimmune diseases and risk of brain tumors within a large, hospital\u2010based case\u2010control study. Cases (\n                    <jats:italic>n<\/jats:italic>\n                    = 782) were patients recently diagnosed with glioma (\n                    <jats:italic>n<\/jats:italic>\n                    = 489), meningioma (\n                    <jats:italic>n<\/jats:italic>\n                    = 197) or acoustic neuroma (\n                    <jats:italic>n<\/jats:italic>\n                    = 96) at hospitals in Boston, Phoenix and Pittsburgh (USA). Controls (\n                    <jats:italic>n<\/jats:italic>\n                    =799) were patients hospitalized for a variety of nonmalignant conditions and frequency\u2010matched to cases by hospital, age, sex, race\/ethnicity and distance of residence from hospital. Research nurses collected data by personal interview of patients. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression. There was a significant inverse association between glioma and history of any allergies (OR = 0.67, 95% CI = 0.52\u20130.86) or autoimmune diseases (OR = 0.49, 95% CI = 0.35\u20130.69). No significant associations were evident for meningioma or acoustic neuroma with history of any allergies. An inverse association was observed between meningioma and history of autoimmune diseases (OR = 0.59, 95% CI = 0.38\u20130.92). There was a suggestion of interaction between allergies and autoimmune diseases on risk of glioma (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.06), with subjects having both conditions being at lowest risk (OR = 0.24, 95% CI = 0.14\u20130.42). Among the specific conditions, asthma and diabetes showed the most consistent associations (OR = 0.63, 95% CI = 0.43\u20130.92 and OR = 0.44, 95% CI = 0.27\u20130.70, respectively). Our results add to evidence that persons with allergies or autoimmune diseases are at reduced risk of glioma. The basis of the associations is not clear, but they might imply a role of immunologic factors in the development of brain tumors. Published 2002 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.10320","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T19:45:33Z","timestamp":1030304733000},"page":"252-259","source":"Crossref","is-referenced-by-count":179,"title":["History of allergies and autoimmune diseases and risk of brain tumors in adults"],"prefix":"10.1002","volume":"99","author":[{"given":"Alina V.","family":"Brenner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha S.","family":"Linet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Fine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Selker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Inskip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1231","volume-title":"Cancer epidemiology and prevention","author":"Preston\u2010Martin S","year":"1996"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1995.tb00588.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036200"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182087"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920515)69:10<2541::AID-CNCR2820691025>3.0.CO;2-H"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910510105"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970410)71:2<203::AID-IJC13>3.0.CO;2-I"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990719)82:2<155::AID-IJC1>3.0.CO;2-P"},{"issue":"1","key":"e_1_2_6_10_2","first-page":"S48","article-title":"Do common allergies prevent brain tumors?","volume":"3","author":"Wrensch M","year":"2001","journal-title":"Neuro\u2010oncology"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01212.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1965.00460280060005"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.18.1360"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110193"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.4.307"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.195"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb00019.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb04941.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.2.161"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/22.3.412"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440201"},{"key":"e_1_2_6_22_2","volume-title":"SAS\/STAT User's Guide, ver. 8","year":"1999"},{"key":"e_1_2_6_23_2","first-page":"611","article-title":"The role of IgE\u2010mediated hypersensitivity in the development of otitis media with effusion: a review","volume":"109","author":"Bernstein JM","year":"1993","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854100778248971"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010017"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116494"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880715)62:2<451::AID-CNCR2820620234>3.0.CO;2-D"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4412"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/152091501300209633"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00009"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.2.600"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(99)00158-0"},{"key":"e_1_2_6_34_2","first-page":"1390","article-title":"The accuracy of self\u2010report of physician diagnosed rheumatoid arthritis in moderately to severely disabled older women. Women's Health and Aging Collaborative Research Group","volume":"27","author":"Ling SM","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.10.850"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101113440206"},{"key":"e_1_2_6_37_2","first-page":"58","article-title":"Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue and to the anterior chamber of the eye","volume":"29","author":"Medawar PB","year":"1948","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1736"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09028-4"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1992.tb00691.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1995.tb02882.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440150308"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(95)00010-0"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01049981"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200101043440106"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-759"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00360.x"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a55250"},{"key":"e_1_2_6_49_2","first-page":"85","article-title":"Natural killer cell activity in asthma","volume":"59","author":"Timonen T","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_50_2","first-page":"1222","article-title":"Mechanisms of CD23 hyperexpression on B cells from patients with rheumatoid arthritis","volume":"28","author":"De Miguel S","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb05718.x"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1258\/0007142001903625"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00904.x"},{"key":"e_1_2_6_54_2","first-page":"1793","article-title":"Influence of longterm therapy with methotrexate and low dose corticosteroids on type 1 and type 2 cytokine production in CD4+ and CD8+ T lymphocytes of patients with rheumatoid arthritis","volume":"28","author":"Schuerwegh AJ","year":"2001","journal-title":"J Rheumatol"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10320","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:41:20Z","timestamp":1697280080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,11]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,5,10]]}},"alternative-id":["10.1002\/ijc.10320"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10320","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,11]]}}}