{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:27:04Z","timestamp":1779114424514,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,3,26]],"date-time":"2002-03-26T00:00:00Z","timestamp":1017100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,5,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The existence of <jats:italic>XAGE<\/jats:italic> genes was first reported after database homology searches for <jats:italic>PAGE<\/jats:italic>\u2010like sequences identified 3 <jats:italic>XAGE<\/jats:italic> EST clusters. One of these clusters, <jats:italic>XAGE\u20101,<\/jats:italic> has in later studies been identified as a cancer\/testis\u2010associated gene. Here, we report the expression profiles of all 3 reported <jats:italic>XAGE<\/jats:italic> genes, as well as several splice variants of <jats:italic>XAGE\u20101,<\/jats:italic> in normal human tissues, Ewing's sarcoma and melanocytic tumors. We also provide the genetic structure of the corresponding genes. Moreover, by searching the databases for <jats:italic>XAGE<\/jats:italic> homologues, we identified 3 additional <jats:italic>GAGE<\/jats:italic>\u2010like genes. RT\u2010PCR studies showed frequent expression in melanoma metastases and Ewing's sarcoma for 2 <jats:italic>XAGE\u20101<\/jats:italic>\u2010derived transcripts. <jats:italic>XAGE\u20102<\/jats:italic> was expressed at lower frequency in these tissues, while <jats:italic>XAGE\u20103<\/jats:italic> was seen only in normal placenta. Due to a frameshift, the largest XAGE\u20101 putative protein is far less homologous to GAGE\u2010like proteins than the other XAGEs. Interestingly, all <jats:italic>GAGE<\/jats:italic>\u2010like genes contain a large secondary open reading frame, coding for putative proteins homologues to the XAGE\u20101 primary protein. The <jats:italic>XAGE<\/jats:italic> family of cancer\/testis\u2010associated genes is located on chromosome Xp11.21\u2010Xp11.22. The data outline a superfamily of <jats:italic>GAGE<\/jats:italic>\u2010like cancer\/testis antigens, consisting of at least 19 genes. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10371","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:45:33Z","timestamp":1030319133000},"page":"361-369","source":"Crossref","is-referenced-by-count":65,"title":["The <i>XAGE<\/i> family of cancer\/testis\u2010associated genes: Alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma"],"prefix":"10.1002","volume":"99","author":[{"given":"Albert J.W.","family":"Zendman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke A.","family":"van Kraats","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich 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