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We present the results of an international case\u2010control study to evaluate the association between CBTs and exposure of parents and children to cigarette smoke. The study was undertaken as part of the SEARCH program of the IARC. Nine centers in 7 countries were involved. The studies mainly covered the 1980s and early 1990s. Cases (1,218, ages 0\u201319 years) were children newly diagnosed with a primary brain tumor; there were 2,223 population\u2010based controls. Most mothers who agreed to participate were interviewed in person at home. Odds ratios (ORs) were calculated by unconditional logistic regression, adjusted for age, sex and center, for all types of CBT combined, 4 CBT histotypes, 5 age groups and each center. There was no association between the risk of brain tumors in the child and parental smoking prior to pregnancy, maternal smoking or regular exposure to others' cigarette smoke during pregnancy at home or at work, or passive smoking by the child during the first year of life. These results did not change considering the child's age at diagnosis, the histologic type of tumor or center. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10465","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:38:48Z","timestamp":1033907928000},"page":"206-213","source":"Crossref","is-referenced-by-count":45,"title":["Relation of childhood brain tumors to exposure of parents and children to tobacco smoke: The Search international case\u2010control study"],"prefix":"10.1002","volume":"100","author":[{"given":"Graziella","family":"Filippini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Maisonneuve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"McCredie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Peris\u2010Bonet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baruch","family":"Modan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Preston\u2010Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Holly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvaine","family":"Cordier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.W.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,14]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Cancer incidence in Five Continents","author":"Parkin DM","year":"1997"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb50392.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/019262330002800125"},{"key":"e_1_2_6_5_2","first-page":"103","article-title":"Teratogenic and carcinogenic effects of some chemicals during prenatal life in rats, Syrian golden hamsters, and guinea pigs","volume":"51","author":"Ivankovic S","year":"1979","journal-title":"Natl Cancer Inst Monogr"},{"key":"e_1_2_6_6_2","first-page":"2656","article-title":"Quantitative aspects of transplacental tumor induction with ethylnitrosourea in rats","volume":"32","author":"Swenberg JA","year":"1972","journal-title":"Cancer Res"},{"key":"e_1_2_6_7_2","first-page":"54","volume-title":"O'Neill IK, Chen J, Bartsch H, eds","author":"Hecht SS"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s3451"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.5.459"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/096032719701601204"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3941892"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.4.274"},{"key":"e_1_2_6_13_2","series-title":"Tobacco smoking. 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