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The PAF for familial breast cancer has not been precisely determined. We used the nationwide Swedish Family\u2010Cancer Database on 10.2 million individuals and 190,000 mothers' and 26,000 daughters' breast cancers to calculate familial standardized incidence ratios (SIRs), proportion of cases with a family history and familial PAFs for all invasive and <jats:italic>in situ<\/jats:italic> and morphology\u2010specific breast cancers in daughters who were 0\u201366 years old. The data were calculated by mother only, sister only or both as probands. More than 5,500 familial breast cancers were recorded. The familial SIRs for all invasive breast cancer were 1.79 by breast cancer in the mother only, 2.03 by breast cancer in a sister only and 2.82 by breast cancer in both a mother and sister. The familial PAFs were 3.61, 3.01 and 0.43%, respectively, giving a total PAF of 7.05%. Age\u2010specific risks were shown for the mother and sister history of breast cancer. The PAF values decreased by age when the daughter had a mother history of breast cancer but not when she had a sister history. PAFs did not depend on the morphologic type of breast cancer. The data show that the familial PAF of breast cancer among a 0\u201366\u2010year\u2010old population of daughters was 7% and independent of the morphologic type. If contribution from the paternal side was allowed for, the PAF would be 11%. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10467","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T12:38:48Z","timestamp":1033907928000},"page":"214-219","source":"Crossref","is-referenced-by-count":42,"title":["Attributable risks for familial breast cancer by proband status and morphology: A nationwide epidemiologic study from Sweden"],"prefix":"10.1002","volume":"100","author":[{"given":"Kari","family":"Hemminki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotta","family":"Granstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,5,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970529)71:5<800::AID-IJC18>3.0.CO;2-B"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06524-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820741312"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1585"},{"key":"e_1_2_6_6_2","first-page":"733","article-title":"The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches","volume":"10","author":"Risch N","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/318187"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_6_9_2","first-page":"114","article-title":"The reliability of recollections of family history: implications for the medical provider","volume":"12","author":"Parent ME","year":"1997","journal-title":"J Cancer Educ"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00093-9"},{"key":"e_1_2_6_11_2","volume-title":"Basic pathology","author":"Kumar V","year":"1997"},{"key":"e_1_2_6_12_2","first-page":"782","article-title":"The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2","volume":"6","author":"Lakhani SR","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.15.1138"},{"key":"e_1_2_6_14_2","article-title":"Familial breast cancer risks by morphology: a nation\u2010wide epidemiologic study from Sweden","author":"Hemminki K","journal-title":"Cancer"},{"key":"e_1_2_6_15_2","article-title":"Morphological types of breast cancer in family members and multiple primary tumours: is morphology an inherited trait?","author":"Hemminki K","journal-title":"Breast Cancer Res"},{"key":"e_1_2_6_16_2","volume-title":"Modern epidemiology","author":"Rothman K","year":"1998"},{"key":"e_1_2_6_17_2","volume-title":"Cancer epidemiology: principles and methods","author":"dos Santos Silva I","year":"1999"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115616"},{"key":"e_1_2_6_19_2","first-page":"232","article-title":"Genetic analysis of breast cancer in the cancer and steroid hormone study","volume":"48","author":"Claus EB","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199205143262004"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1001\/jama.1993.03510130069033","article-title":"A comprehensive evaluation of family history and breast cancer risk. 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