{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:24:05Z","timestamp":1774437845647,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,5,29]],"date-time":"2002-05-29T00:00:00Z","timestamp":1022630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>p53<\/jats:italic> codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix. However, there have been no reports on the <jats:italic>p53<\/jats:italic> codon 72 polymorphism in gastric cancer susceptibility in patients with <jats:italic>Helicobacter pylori\u2010<\/jats:italic>associated chronic gastritis (<jats:italic>H. pylori<\/jats:italic>\u2010CG). We, therefore, examined the polymorphism in 117 gastric cancer patients (72 intestinal type and 45 diffuse type) with <jats:italic>H. pylori<\/jats:italic>\u2010CG and 116 <jats:italic>H. pylori<\/jats:italic>\u2010CG patients without gastric cancer as controls. Polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) analysis was performed to analyze the <jats:italic>p53<\/jats:italic> codon 72 polymorphism. The crude genotypic frequencies in the gastric cancer patients were similar to those of the controls. However, when gastric cancers were classified by histologic subtype, the Pro\/Pro was more frequent in the patients with diffuse type gastric cancer than in the controls (22.2% of cases <jats:italic>vs.<\/jats:italic> 12.1% of controls). The Pro\/Pro genotype was associated with a 2.98\u2010fold higher risk of diffuse\u2010type cancer compared to the Arg\/Arg genotype (95% confidence interval [CI] 1.07\u20138.32, <jats:italic>p<\/jats:italic> = 0.038). These results suggest that the Pro\/Pro genotype at <jats:italic>p53<\/jats:italic> codon 72 contributes to susceptibility for diffuse\u2010type gastric cancer in patients with <jats:italic>H. pylori<\/jats:italic>\u2010CG. The <jats:italic>p53<\/jats:italic> codon 72 polymorphism may serve as the genetic marker for the risk assessment of the diffuse\u2010type gastric cancer development in patients with <jats:italic>H. pylori<\/jats:italic>\u2010CG. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10483","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:05:28Z","timestamp":1031709928000},"page":"304-308","source":"Crossref","is-referenced-by-count":56,"title":["<i>p53<\/i> Codon 72 polymorphism in gastric cancer susceptibility in patients with <i>Helicobacter pylori<\/i>\u2010associated chronic gastritis"],"prefix":"10.1002","volume":"100","author":[{"given":"Toru","family":"Hiyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Kitadai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Sumii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Shimamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Haruma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90421-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(1998100)186:2<131::AID-PATH158>3.0.CO;2-1"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8259506"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.19.1554"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90155-A"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.12.7805"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/30400"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07357-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.4.583"},{"key":"e_1_2_5_11_2","first-page":"1037","article-title":"The p53 codon 72 polymorphism and lung cancer risk","volume":"9","author":"Fan R","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000920)89:5<458::AID-IJC10>3.0.CO;2-R"},{"key":"e_1_2_5_13_2","first-page":"2753","article-title":"p53 polymorphism in human papillomavirus\u2010associated esophageal cancer","volume":"60","author":"Kawaguchi H","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.48.1.6"},{"key":"e_1_2_5_15_2","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process\u2010First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb00514.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655200750024100"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70356-8"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.1965.64.1.31"},{"key":"e_1_2_5_20_2","volume-title":"Classification of gastric carcinoma","author":"Japanese Research Society for Gastric Cancer","year":"1995"},{"key":"e_1_2_5_21_2","first-page":"201161","article-title":"Classification and grading of gastritis: the Updated Sydney System","author":"Dixon MF","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.16.4961"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/83.23.1734"},{"key":"e_1_2_5_24_2","first-page":"177","volume-title":"Helicobacter pylori. 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