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Previous studies have revealed that the formulated ethanol extract (DA\u20109601) of <jats:italic>A. asiatica<\/jats:italic> has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects against experimentally induced gastrointestinal, hepatic and pancreatic damage. In the present study, we assessed the inhibitory effect of DA\u20109601 on tumor promotion, which is closely linked to inflammatory tissue damage. As an initial approach to evaluating the possible antitumor\u2010promoting potential of DA\u20109601, its effects on TPA\u2010induced ear edema were examined in female ICR mice. Pretreatment of the inner surface of the mouse ear with DA\u20109601 30 min prior to topical application of TPA inhibited ear edema at 5 hr. TPA\u2010stimulated expression of epidermal COX\u20102 and iNOS was also mitigated by topical application of the same extract. Moreover, DA\u20109601 abrogated the TPA\u2010mediated activation of NF\u2010\u03baB\/Rel and AP\u20101 in mouse epidermis. Suppression of epidermal NF\u2010\u03baB by DA\u20109601 appeared to be mediated in part through inhibition of I\u03baB\u03b1 degradation, thereby blocking the nuclear translocation of p65, the functional subunit of NF\u2010\u03baB. DA\u20109601 also significantly suppressed TPA\u2010induced ODC activity and papilloma formation in mouse skin. Taken together, these findings suggest that DA\u20109601 derived from <jats:italic>A. asiatica<\/jats:italic> possesses potential chemopreventive activities. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10489","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:05:28Z","timestamp":1031709928000},"page":"456-462","source":"Crossref","is-referenced-by-count":61,"title":["Inhibitory effects of the standardized extract (DA\u20109601) of <i>Artemisia asiatica<\/i> Nakai on phorbol ester\u2013induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase\u20102 expression, inducible nitric oxide synthase expression and nuclear transcription factor \u03baB activation in mouse 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