{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:39:33Z","timestamp":1770496773493,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,6,13]],"date-time":"2002-06-13T00:00:00Z","timestamp":1023926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fonds de la Recherche en Sant\u00e9 du Qu\u00e9bec"},{"DOI":"10.13039\/501100000024","name":"Canadian Institute for Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Breast Cancer Research Initiative"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic analyses and mRNA expression studies have implicated <jats:italic>CUTL1<\/jats:italic> as a candidate tumor\u2010suppressor gene in uterine leiomyomas and breast cancers. However, modulation of CDP\/Cux, the protein encoded by <jats:italic>CUTL1,<\/jats:italic> does not agree with this notion. The activity of CDP\/Cux, which is the DNA binding subunit of HiNF\u2010D, was upregulated as normal cells progressed into S phase and constitutively elevated in several tumor cell lines. Activation of CDP\/Cux at the G<jats:sub>1<\/jats:sub>\/S transition involved the proteolytic processing of the protein to generate a shorter isoform. Uterine leiomyomas represent a unique reagent for molecular analysis because they are resected as homogenous tumor tissue together with the adjacent normal myometrium and they are often very large. In the present study, proteins were isolated from 16 pairs of matched tumors and adjacent myometrium and analyzed by Western blot and electrophoretic mobility shift assays. Strikingly, in 11\/16 tumors, the steady\u2010state level of small CDP\/Cux isoforms was increased compared to normal control tissue. Where tested, a corresponding increase in CDP\/Cux stable DNA binding activity was observed. DNA sequencing analysis of <jats:italic>CUTL1<\/jats:italic> cDNAs from 6 leiomyomas, including 4 with LOH of <jats:italic>CUTL1,<\/jats:italic> did not reveal any gross rearrangement or point mutations. Altogether these findings suggest that <jats:italic>CUTL1<\/jats:italic> is probably not the tumor suppressor on 7q22. Moreover, the frequent increase in smaller CDP\/Cux isoforms indicates that molecular events associated with the truncation of CDP\/Cux proteins may be selected in uterine leiomyomas. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.10510","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T02:05:28Z","timestamp":1031709928000},"page":"429-432","source":"Crossref","is-referenced-by-count":30,"title":["Expression of N\u2010terminally truncated isoforms of CDP\/CUX is increased in human uterine leiomyomas"],"prefix":"10.1002","volume":"100","author":[{"given":"Nam Sung","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Rong Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Premdas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Santaguida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginette","family":"B\u00e9rub\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Nepveu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,6,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90195-R"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016336"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199404000-00011"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050073"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/2.4.277"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0895-436"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870140109"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199707)19:3<156::AID-GCC4>3.0.CO;2-X"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201076"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90151-1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202519"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"15034","DOI":"10.1016\/S0021-9258(18)63807-4","article-title":"Human H4 histone gene transcription requires the proliferation\u2010specific nuclear factor HiNF\u2010D. Auxiliary roles for HiNF\u2010C (Sp1\u2010like) and HiNF\u2010A (high mobility group\u2010like)","volume":"264","author":"van Wijnen AJ","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11516"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0492-50"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2321007"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00125a023"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19970915)66:4<512::AID-JCB10>3.0.CO;2-D"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.6.2573"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(01)00485-1"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.7.3587"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041590316"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107978200"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.16.4680"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.18.6332-6345.2001"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1050>3.0.CO;2-1"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.8.10.1060"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00465-5"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.10510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.10510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T22:17:27Z","timestamp":1697494647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.10510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,13]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1002\/ijc.10510"],"URL":"https:\/\/doi.org\/10.1002\/ijc.10510","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,13]]}}}